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Epiallopregnanolone

Catalog No.
C4172
inactive as a GABAA receptor modulator and used as a control substance to examine GABA neurotransmission.
Grouped product items
SizePriceStock Qty
5mg
$104.00
Ship with 5-10 days
10mg
$185.00
Ship with 5-10 days
25mg
$405.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Epiallopregnanolone (CAS 567-01-1) is an endogenous neurosteroid metabolite derived from progesterone, structurally characterized as the 3β-isomer of allopregnanolone. Epiallopregnanolone functions mainly as a competitive antagonist at neurosteroid binding sites on GABA_A receptors, ligand-gated chloride channels essential for neuronal inhibition. In vitro, it selectively inhibits allopregnanolone-induced chloride ion flux and antagonizes allopregnanolone and ethanol-mediated suppression of hippocampal CA1 population spikes. In vivo experiments indicate epiallopregnanolone reduces ethanol discrimination behavior in trained rats. Its selective GABA receptor antagonism supports utility in neuroactive steroid and ethanol interaction research.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt334.5
Cas No.567-01-1
FormulaC21H34O3
Synonyms5α-Pregnan-20-one,3β,21-dihydroxy-5α-Pregnan-20-one,3β,5α-Tetrahydrodeoxycorticosterone,3β,5α-Tetrahydroprogesterone
Solubility≤25mg/ml in ethanol;25mg/ml in DMSO;25mg/ml in dimethyl formamide
Chemical Name3,21-dihydroxy-, (3?,5α)-pregnan-20-one
Canonical SMILESC[C@](CC1)([C@@H](CC2)[C@H](CC3)[C@H]1[C@@](C)(CC1)[C@@H]3C[C@H]1O)[C@H]2C(CO)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Epiallopregnanolone
 

User Guide

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