一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

4-phenyl-5-methyl-1,2,3-Thiadiazole

Catalog No.
C4429
CYP2B4 and CYP2E1 inhibitor
Grouped product items
SizePriceStock Qty
1g
$280.00
Ship with 5-10 days
5g
$700.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

4-phenyl-5-methyl-1,2,3-Thiadiazole is a CYP2B4 and CYP2E1 inhibitor.

Cytochrome P450 (CYP450) enzymes, a superfamily of oxidative catalysts, are important in the biosynthesis and metabolism of a wide range of endogenous molecules and the metabolism of xenobiotics. CYP2B4 can metabolize substituted amines, while CYP2E1 metabolizes various alcohols and halogenated alkenes.

In vitro: 4-phenyl-5-methyl-1,2,3-Thiadiazole (PMT) was found to be slightly more inhibitory to P450s 2E1 and 1A2 than its close analog, 4,5-diphenyl-1,2,3-thiadiazole (DPT). By contrast, 4-phenyl-5-hydrogen-1,2,3-Thiadiazole (PT), a weaker inhibitor than DPT and PMT with P450s 2E1 and 2B4, was comparable to PMT and more effective than DPT with P450 1A2. Moreover, PMT, DPT, as well as PT showed no inactivation of either P450 2E1 or 2B4, though they were fairly effective inhibitors, and the thiadiazole ring could be oxidized by the P450 system. Furthremore, the lack of inactivation of the P450 isoforms by PMT, DPT, and PT suggested that a transient reactive intermediate was not formed on oxidation of the thiadiazole ring. In additioin, the 1,2,3-thiadiazole ring could be oxidized by the P450 system [1].

In vivo: Up to now, there is no animla in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Babu, B. R. and Vaz, A.D.N. 1,2,3-thiadiazole: A novel heterocyclic heme ligand for the design of cytochrome P450 inhibitors. Biochemistry 36, 7209-7216 (1997).

Chemical Properties

StorageStore at -20°C
M.Wt176.2
Cas No.64273-28-5
FormulaC9H8N2S
SynonymsNSC 358739
Solubilityinsoluble in H2O; ≥10.38 mg/mL in EtOH; ≥7.85 mg/mL in DMSO
Chemical Name5-methyl-4-phenyl-1,2,3-thiadiazole
Canonical SMILESCc1c(-c2ccccc2)nn[s]1
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

4-phenyl-5-methyl-1,2,3-Thiadiazole
 

User Guide

抚州市| 河池市| 霸州市| 邹平县| 特克斯县| 阿巴嘎旗| 商洛市| 宝应县| 大英县| 全州县| 石屏县| 潼关县| 中阳县| 昌吉市| 南江县| 龙泉市| 禄劝| 子长县| 凌云县| 宜君县| 介休市| 汽车| 洛浦县| 皋兰县| 建湖县| 古蔺县| 吉林省| 迭部县| 晋宁县| 永登县| 漳州市| 攀枝花市| 奉新县| 沧源| 扬中市| 新泰市| 马公市| 平定县| 于都县| 宁德市| 霍邱县|