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Eflornithine hydrochloride

Catalog No.
C8761
An irreversible ornithine decarboxylase (ODC) inhibitor
Grouped product items
SizePriceStock Qty
100mg
$50.00
Ship with 5-10 days
500mg
$135.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Eflornithine hydrochloride (DFMO, CAS No. 68278-23-9) is a mechanism-based irreversible inhibitor of ornithine decarboxylase (ODC), blocking the rate-limiting step of polyamine synthesis (putrescine→spermidine/spermine decrease), thereby inhibiting cell proliferation, commonly manifested as G1-phase arrest; its effects can be reversed by supplementation with exogenous polyamines. Clinically, it is used for African trypanosomiasis (T. b. gambiense) and topical hair growth inhibition; it is also commonly used as a polyamine-pathway tool compound in tumors (e.g., neuroblastoma, chemoprevention of colorectal cancer).

For experimental applications, at the cellular level it is commonly used at a final concentration of ~0.5–5 mM (often 1 mM or 5 mM) for 24–96 h to deplete polyamines and observe changes in proliferation/colony formation/stemness, etc.; at the animal level, oral administration is most often used (administration via drinking water is common, e.g., ~1–2% w/v continuous dosing; or gavage/oral divided dosing as designed in the literature). The actual intake dose fluctuates with water consumption and model differences, and the dosing window is typically calibrated by monitoring body weight, water intake, and tissue/urinary polyamine levels.

References:

[1] Romijn JC, Verkoelen CF, Splinter TA. Problems of pharmacokinetic studies on alpha-difluoromethylornithine in mice. Cancer Chemother Pharmacol. 1987;19(1):30-4. doi: 10.1007/BF00296251. PMID: 3102094.

[2] Bock JM, Pickart MA, Pink JJ, Harari PM. Modulation of tumor cell proliferation and apoptosis by polyamine depletion in cells of head and neck squamous cell carcinomas. Radiat Res. 1999 Dec;152(6):604-10. PMID: 10581530.

Chemical Properties

StorageStore at -20°C
M.Wt218.63
Cas No.68278-23-9
FormulaC6H13ClF2N2O2
SynonymsDFMO HCl; Vaniqa; NSC 270295; NSC 337250
Chemical Name2,5-diamino-2-(difluoromethyl)pentanoic acid hydrochloride
Canonical SMILESCl.O=C(O)C(N)(CCCN)C(F)F
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

User Guide

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