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Ivermectin B1a

Catalog No.
C3905
main component of the anthelmintic, ivermectin;glutamate-gated chloride channels opener
Grouped product items
SizePriceStock Qty
5mg
$183.00
Ship with 5-10 days
25mg
$825.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Ivermectin B1a (CAS 71827-03-7) is the primary constituent (≥80%) of the antiparasitic macrocyclic lactone, ivermectin. Its pharmacological effects originate from selective interaction with glutamate-gated chloride ion channels prevalent in neurons and pharyngeal muscles of nematodes. This binding induces durable chloride influx, causing sustained hyperpolarization or depolarization, resulting in neuromuscular paralysis. Ivermectin displays potent antiparasitic efficacy (EC?? ≈104 nM) and is clinically significant in treating human onchocerciasis, reducing symptoms associated with the infection.

Chemical Properties

Physical AppearanceA white solid
StorageStore at -20°C
M.Wt875.1
Cas No.71827-03-7
FormulaC48H74O14
Synonymsdihydro Avermectin B1a,22,23-dihydro Avermectin B1a
SolubilitySoluble in DMSO
Chemical Name5-O-demethyl-22,23-dihydro-avermectin A1a
Canonical SMILESC/C([C@@H](O[C@@]1([H])C[C@H](OC)[C@@H](O[C@]2([H])O[C@@H](C)[C@H](O)[C@@H](OC)C2)[C@H](C)O1)[C@@H](C)/C=C/C=C(CO3)/[C@@]([C@@]3([H])[C@H](O)C(C)=C4)(O)[C@]4([H])C5=O)=C\C[C@]6([H])C[C@@](O5)([H])C[C@]7(CC[C@H](C)[C@]([C@H](CC)C)([H])O7)O6
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Ivermectin B1a
 

User Guide

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