一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Toggle Nav
Close
  • Menu
  • Setting

Statil

Catalog No.
C3049
aldose reductase inhibitor
Grouped product items
SizePriceStock Qty
10mg
$77.00
Ship with 5-10 days
25mg
$124.00
Ship with 5-10 days
50mg
$171.00
Ship with 5-10 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

IC50: 21.0 nM

Statil, also known as ICI 128436, is an aldose reductase inhibitor, inhibits the conversion of glucose to sorbitol. Statil has the ability to activate the activity of lipoprotein lipase (LPL) both in vivo and in vitro. Also, statil alleviates the cachectic symptoms induced by B16 melanoma in mice. LPL, as a key regulatory enzyme, is responsible for the hydrolysis of triglyceride-rich lipoproteins.

In vitro: Statil strongly, dose-dependently, inhibited the enzyme activity of tumor marker Aldo-keto reductase 1B10. In addition, statil suppressed the cell growth and proliferation dose-dependently in both lung cancer cells NCI-H460 and breast cancer cells BT-20. Also, it was shown that statil induced apoptotic cell death [1].

In vivo: Statil was given to diabetic male rats at 25mg/kg orally by gavage once daily. After five days, statil inhibited rat, bovine, and human aldose reductase and reduced sorbitol levels in sciatic nerve, retina, lens, and renal cortex. Moreover, statil played an important role in rodent models of the lenticular and neural complications of diabetes. And the development of cataracts was completely prevented in diabetic rats at doses as low as 25 mg/kg daily [2].

References:
[1].  Cao, Z., Zhou, B., Chen, X., Huang, D., Zhang, X., & Wang, Z. et al. Statil suppresses cancer cell growth and proliferation by the inhibition of tumor marker AKR1B10. Anti-Cancer Drugs, 2014; 25(8): 930-937.
[2].  Stribling, D., Mirrlees, D., Harrison, H., & Earl, D. Properties of ICI 128,436, a novel aldose reductase inhibitor, and its effects on diabetic complications in the rat. Metabolism, 1985; 34(4): 336-344.

Chemical Properties

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt391.2
Cas No.72702-95-5
FormulaC17H12BrFN2O3
SynonymsICI 128436,MK-538,Ponalrestat
Solubility≤2mg/ml in ethanol;2mg/ml in DMSO;2mg/ml in dimethyl formamide
Chemical Name3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic acid
Canonical SMILESOC(CC(c1ccccc11)=NN(Cc(ccc(Br)c2)c2F)C1=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Statil
 

User Guide

郎溪县| 宜城市| 华坪县| 杂多县| 安化县| 安泽县| 百色市| 慈利县| 赤城县| 策勒县| 北流市| 玉山县| 永胜县| 专栏| 舞阳县| 兴和县| 周口市| 亚东县| 平昌县| 甘谷县| 汤阴县| 贵州省| 青海省| 五家渠市| 雷州市| 威宁| 朝阳区| 平湖市| 商河县| 井冈山市| 恩施市| 博爱县| 青川县| 襄樊市| 修武县| 东丰县| 成安县| 崇仁县| 慈利县| 平湖市| 融水|