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Cilazapril

Catalog No.
B3297
ACE inhibitor
Grouped product items
SizePriceStock Qty
10mg
$136.00
Ship with 10-15 days
50mg
$547.00
Ship with 10-15 days
100mg
$958.00
Ship with 10-15 days
For scientific research use only and should not be used for diagnostic or medical purposes.

Tel: +1-832-696-8203

Email: [email protected]

Worldwide Distributors

Background

Cilazapril is an inhibitor of angiotensin converting enzyme (ACE) with IC50 value of 1.93nM [1].

Cilazapril is a monoethyl prodrug of cilazaprilat. The latter shows an IC50 value of 1.93nM to rabbit lung ACE when using Hip-His-Leu substrate in vitro. Cilazaprilat is most potent among all the ACE inhibitors when the ACE is from rabbit lung, human plasma, hog kidney or human lung. Cilazaprilat is specific. It shows no inhibition to a variety of lipolytic and proteolytic enzymes even the concentration of it is up to more than 10000 fold higher than its IC50 value. Cilazapril and cilazaprilat also show inhibition of the angiotensin I (AI) pressor response with ED50 vallues of 0.44 and 0.06 mmol/kg. In addition, when cilazapril is treated as an antihypertensive drug, the maximum decrease in blood pressure relative to the control is 110mmHg on day 21 [1].

References:
[1] Waterfall JF. A review of the preclinical cardiovascular pharmacology of cilazapril, a new angiotensin converting enzyme inhibitor. Br J Clin Pharmacol. 1989;27

Chemical Properties

StorageDesiccate at -20°C
M.Wt417.5
Cas No.88768-40-5
FormulaC22H31N3O5
SolubilitySoluble in DMSO
Chemical Name(4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid
Canonical SMILESCCOC([C@H](CCc1ccccc1)N[C@@H](CCCN(CCC1)N2[C@@H]1C(O)=O)C2=O)=O
Shipping ConditionSmall Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips We do not recommend long-term storage for the solution, please use it up soon.

Quality Control

Quality Control & MSDS

View current batch:

Chemical structure

Cilazapril
 

User Guide

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