3PO
Catalog No.
B4939
inhibitor of the PFKFB3 isozyme
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3PO (CAS: 13309-08-5; 18550-98-6) is a small molecule inhibitor targeting 6-phosphofructo-2-kinase (PFKFB3), a regulatory enzyme involved in cellular glucose metabolism. Its mode of action involves inhibiting PFKFB3 activity, leading to reduced intracellular synthesis of fructose-2,6-bisphosphate and consequently decreased glycolytic flux. By perturbing glucose metabolism, 3PO modulates cellular proliferation, growth, and survival pathways. The compound is widely used in cell and animal model studies exploring tumor metabolism, metabolic disorders, and immunometabolism.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 210.23 |
| Cas No. | 18550-98-6 |
| Formula | C13H10N2O |
| Solubility | insoluble in H2O; ≥39.6 mg/mL in DMSO; ≥5.63 mg/mL in EtOH with ultrasonic |
| Chemical Name | (E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one |
| Canonical SMILES | O=C(/C=C/c1cnccc1)c1ccncc1 |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Chemical structure
