Leupeptin hemisulphate
Catalogue Number BIMI2183
Synonym(s): Ac-Leu-Leu-argininal hemisulphate
Leupeptin hemisulphate is a protease inhibitor that is produced naturally by some species of the soil bacteria Streptomyces and thus inhibits the degradation of proteins. Unlike many synthetic protease inhibitors, it has very low toxicity to humans. It is a reversible inhibitor of serine and cyst... Read More
- CAS Number
103476-89-7
- Commodity Code
2925290090
- MDL Number
MFCD00037012
- Purity
- >90%
- Notes
- Leupeptin is a peptide antibiotic, isolated from several Streptomyces species. It is a reversible inhibitor ofserine and cysteine proteases
- Formula Weight
- 951.18552 g/mol
- Chemical Hazard
- Irritant
- GHS
-
- Hazard Statements
-
H315: Causes skin irritation.
H319: Causes serious eye irritation.
H335: May cause respiratory irritation.
- Precautionary Statements
-
P261: Avoid breathing {{{0|||message=<specify applicable conditions>|||default=dust/fume/gas/mist/vapours/spray|||filter=(_)?P261_INHAL_CONDITION_.+}}}.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear {{{0|||message=<specify protection eq: hazard.P261: Avoid breathing {{{0|||message=<specify applicable conditions>|||default=dust/fume/gas/mist/vapours/spray|||filter=(_)?P261_INHAL_CONDITION_.+}}}.
P271: Use only outdoors or in a well-ventilated area.
P280: Wear {{{0|||message=<specify protection eq
- MSDS
- Typical Batch COA
- View
- Request batch specific COA here
Product Description
Leupeptin hemisulphate is a protease inhibitor that is produced naturally by some species of the soil bacteria Streptomyces and thus inhibits the degradation of proteins. Unlike many synthetic protease inhibitors, it has very low toxicity to humans. It is a reversible inhibitor of serine and cysteine proteases. It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
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