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IA18018 - Atorvastatin lactam sodium salt impurity

IA18018

Atorvastatin lactam sodium salt impurity

Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[148217-40-7]
Synonyms
(b-R,?R)-5-(4-Fluorophenyl)-2,3-dihydro-b,?-dihydroxy-3-(1-methylethyl)-2-oxo-4-phenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptan oic acid sodium salt
Product Code
IA18018
MDL No
MFCD28143545
MOL file
Chemical Formula
C33H34FN2NaO6
Molecular Weight
596.62 g/mol
Smiles
CC(C)C1(C(=C(N(C1=O)CC[C@H](C[C@H](CC(=O)[O-])O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4.[Na+]
Long Term Storage
store at <-15°C, close container well
Storage
store at <-15°C, close container well
Harmonized Tariff Codes
Switzerland: 29242980 - USA: 2924299500 - Slovakia: 2924297058 - UK: 2924290000 - China: 2924299099
Atorvastatin is a drug used for the treatment of hypercholesterolemia and cardiovascular diseases. Atorvastatin lactam, which is an impurity formed during the synthesis of atorvastatin, has been shown to inhibit cholesterol biosynthesis in a rat model. The in vivo metabolism of atorvastatin lactam was studied by HPLC-MS/MS and was found to be identical to that of the parent molecule. This impurity may be useful as a research and development or custom synthesis product, or as an impurity standard for HPLC analysis.
  1. Roger, D., et al., Clin. Exp. Dermatol., 19, 88
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CoA (Example)
IA18018 CofA
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