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AD21240 - N'-Desmethyl azithromycin

AD21240

N'-Desmethyl azithromycin

N'-Desmethyl azithromycin is a semi-synthetic derivative antibiotic, which is derived from the chemical modification of azithromycin, a macrolide antibiotic sourced originally from the bacterium *Streptomyces erythreus*. It functions primarily b... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[172617-84-4]
Synonyms
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3, 5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(methylamino)-b-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-
Product Code
AD21240
MOL file
Chemical Formula
C37H70N2O12
Molecular Weight
734.96 g/mol
Smiles
CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)NC)O)(C)O)C)C)C)O)(C)O
Harmonized Tariff Codes
Switzerland: 29419000 - USA: 2941905000 - Slovakia: 2941900000 - UK: 2941900000 - China: 2941909099
N'-Desmethyl azithromycin is a semi-synthetic derivative antibiotic, which is derived from the chemical modification of azithromycin, a macrolide antibiotic sourced originally from the bacterium *Streptomyces erythreus*. It functions primarily by inhibiting bacterial protein synthesis, binding specifically to the 50S ribosomal subunit, which results in the prevention of transpeptidation and translocation processes during translation. This action effectively halts bacterial growth, rendering it bacteriostatic.

The primary applications of N'-Desmethyl azithromycin are rooted in its antibacterial properties. It is utilized in the research context to study resistance mechanisms and pharmacokinetics of azithromycin and its derivatives. Additionally, its unique structure allows exploration into formulation strategy, improved bioavailability, and extended spectrum of macrolide antibiotics. While not typically used in clinical settings independently, it serves as an important component in the development of new antibiotics and understanding the metabolism and efficacy of macrolide antibiotics.

  1. Bright, G., et al., J. Antibiot., 41, 1029

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TSE-BSE declaration N'-Desmethyl azithromycin AD21240
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Retest Statement N'-Desmethyl azithromycin AD21240
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