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J-030005 - Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

J-030005

Polyinosinic acid-polycytidylic acid, homopolymer (1:1)

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex st... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[24939-03-5]
Synonyms
Poly-I:C
Poly-IC
Poly IC
Additional Synonyms
Poly I:C
Product Code
J-030005
MOL file
Chemical Formula
(C10H13N4O8P)x?(C9H14N3O8P)x
Smiles
C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)O)O)O
Long Term Storage
store at <-15°C
Storage
store at <-15°C
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29349900 - USA: 2934993900 - Slovakia: 2934999090 - UK: 2934999090 - China: 2934999099

Polyinosinic acid-polycytidylic acid (Poly I:C), an agonist of TLR3 toll-like receptors, is a synthetic double-stranded RNA analog, consisting of polyinosinic acid (poly I) paired with polycytidylic acid (poly C), forming a stable duplex structure.

PolyI:C stimulates the secretion of pro-inflammatory cytokines and type I interferon through its interaction with endosomal Toll-like receptor 3 (TLR-3) and the cytoplasmic receptors melanoma differentiation-associated gene 5 (MDA-5) and retinoic acid-inducible gene I (RIG-I). This immunostimulant activity makes Poly I:C a useful vaccine adjuvant and is used in vaccine formulations. 

Poly I:C and its stabilized analogs (e.g., poly-ICLC) are also being actively researched for their dual role in oncology: directly targeting tumors and acting as immune potentiators. For example Poly I:C can induce apoptosis in tumor cells and stimulate immunogenic cell death and is therefore being explored alongside chemotherapy, radiotherapy, and checkpoint inhibitors, helping to overcome resistance mechanisms and strengthen treatment outcomes.

We can supply PolyI:C to all stages of your project - from R&D and preclinical phases right up to GMP commercial manufacture. Contact our team for custom Poly I:C products.

For more on poly I:C read out blog 'Poly I:C: A Vaccine Adjuvant With Oncological Potential.'

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Specification
English
CoA (Example)
J-030005 CofA
MSDS
Request MSDS
TSE / BSE Statement
TSE-BSE declaration Polyinosinic acid-polycytidylic acid, homopolymer (1:1) J-030005
Retest Statement
Retest Statement Polyinosinic acid-polycytidylic acid, homopolymer (1:1) J-030005
CoA (Example)
J-030005 CofA
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