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NA16496 - trans-Abacavir dihydrochloride

NA16496

trans-Abacavir dihydrochloride

trans-Abacavir dihydrochloride is a synthetic compound classified as a nucleoside analog. It is derived from chemical synthesis and serves as a prodrug that is metabolized in the body to its active form, carbovir triphosphate. Its primary mode o... Read More
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CAS No
[267668-71-3]
Synonyms
(1R,4R)-rel-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol hydrochloride
Product Code
NA16496
MDL No
MFCD18427212
MOL file
Chemical Formula
C14H18N6O·2HCl
Molecular Weight
359.25 g/mol
Smiles
C1CC1NC2=C3C(=NC(=N2)N)N(C=N3)[C@@H]4C[C@H](C=C4)CO.Cl
Harmonized Tariff Codes
Switzerland: 29339900 - USA: 2933999701 - Slovakia: 2933991000 - UK: 2933990000 - China: 2933990099
trans-Abacavir dihydrochloride is a synthetic compound classified as a nucleoside analog. It is derived from chemical synthesis and serves as a prodrug that is metabolized in the body to its active form, carbovir triphosphate. Its primary mode of action involves the inhibition of the HIV-1 reverse transcriptase enzyme. This inhibition is achieved through the incorporation of the active metabolite into viral DNA, resulting in chain termination and preventing viral replication.

trans-Abacavir dihydrochloride is employed extensively in the management of HIV-1 infections. It is a vital component of combination antiretroviral therapy (ART), where it works synergistically with other antiretrovirals to reduce the viral load in patients. Its efficacy in lowering viral replication assists in the management of the disease and improves patient outcomes. Although the compound is effective, its use requires monitoring for potential hypersensitivity reactions, necessitating genetic testing for HLA-B*5701 to ensure patient safety.
  1. Foster, R., et al., Drugs, 55, 729 (1998)
  2. Hanumegowda, U., et al., Chem. Res. Toxicol., 23, 749 (2010)
  3. Prasse, C., et al., Environ. Sci. Technol., 44, 1728 (2010)
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TSE / BSE Statement
TSE-BSE declaration trans-Abacavir dihydrochloride NA16496
Retest Statement
Retest Statement trans-Abacavir dihydrochloride NA16496
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