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IF46257 - 11-Fluoro desloratadine

IF46257

11-Fluoro desloratadine

11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with f... Read More
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CAS No
[298220-99-2]
Synonyms
Desloratadine impurity A
8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Product Code
IF46257
MOL file
Chemical Formula
C19H20N2ClF
Molecular Weight
330.83 g/mol
Smiles
C1CNCCC1C2(C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)F
Long Term Storage
store at <-15°C, close container well
Storage
store at <-15°C, close container well
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29333900 - USA: 2933396191 - Slovakia: 2933399990 - UK: 2933399999 - China: 2933399099
11-Fluoro desloratadine is a metabolite of the antihistamine, loratadine. It has shown to be an analytical standard for HPLC, and impurity standard for pharmacopoeia. 11-Fluoro desloratadine is typically synthesized by reacting loratadine with fluorinating reagent such as N-fluorosuccinimide (NFSI) in the presence of a base catalyst such as sodium methoxide. 11-Fluoro desloratadine is also found in breast milk at concentrations of up to 1.2% of total loratadine concentration, which has been attributed to incomplete metabolism or passive transfer from mother to child.
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CoA (Example)
IF46257 CofA
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