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QXA45341 - (2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid

QXA45341

(2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid

(2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid is an inhibitor that binds to the active site of protein kinase A (PKA). It is a noncompetitive inhibitor with a Ki of 0.03 μM for PKA. The ... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[565453-41-0]
Product Code
QXA45341
MOL file
Chemical Formula
C19H27F3N2O6
Molecular Weight
436.4 g/mol
Smiles
C1CC(N(C1)C(=O)CNC23CC4CC(C2)CC(C4)(C3)O)C(=O)O.C(=O)(C(F)(F)F)O
Melting Point
80 °C
Long Term Storage
store at 10°C - 25°C
Storage
store at 10°C - 25°C
Precautionary Statement Code
P261, P262
(2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid is an inhibitor that binds to the active site of protein kinase A (PKA). It is a noncompetitive inhibitor with a Ki of 0.03 μM for PKA. The inhibition of PKA by this drug has been shown to enhance the activation of glycogen synthase kinase 3β (GSK3β) and increase the phosphorylation of β-catenin at Ser33. This drug has also been shown to inhibit ion channels such as voltage gated sodium channels and calcium channels.
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Specification
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MSDS
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TSE / BSE Statement
TSE-BSE declaration (2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid QXA45341
Retest Statement
Retest Statement (2S)-1-[2-[(3-Hydroxy-1-adamantyl)amino]acetyl]pyrrolidine-2-carboxylic acid 2,2,2-trifluoroacetic acid QXA45341
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