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FN70167 - 2-Nitro-3,4,5-trimethoxybenzoic acid

FN70167

2-Nitro-3,4,5-trimethoxybenzoic acid

2-Nitro-3,4,5-trimethoxybenzoic acid (2-NTMB) is a potent anticancer agent that has shown cytotoxic effects in human epidermoid carcinoma cells. It inhibits the growth of cancer cells by interfering with their DNA synthesis and repair. 2-NTMB bi... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[66907-52-6]
Product Code
FN70167
MDL No
MFCD00017005
MOL file
Chemical Formula
C10H11NO7
Molecular Weight
257.2 g/mol
Smiles
COC1=C(C(=C(C(=C1)C(=O)O)[N+](=O)[O-])OC)OC
Melting Point
166 °C
Long Term Storage
store at 10°C - 25°C, close container well
Storage
store at 10°C - 25°C, close container well
Hazard Statement Code
H315, H319, H335
Precautionary Statement Code
P261, P280, P302+P352, P304+P340, P305+P351+P338, P501
GHS Information
GHS Code GHS07
Harmonized Tariff Codes
Switzerland: 29189900 - USA: 2918995000 - Slovakia: 2918999090 - UK: 2918999090 - China: 2918990090
2-Nitro-3,4,5-trimethoxybenzoic acid (2-NTMB) is a potent anticancer agent that has shown cytotoxic effects in human epidermoid carcinoma cells. It inhibits the growth of cancer cells by interfering with their DNA synthesis and repair. 2-NTMB binds to DNA and blocks the action of enzymes involved in DNA synthesis and repair. This binding leads to cancer cell death through irradiation or by blocking the production of new proteins vital for cell division. 2-NTMB is bioisosteric with combretastatin A4, which means it can be substituted for this drug without significant loss of potency. It also has been shown to be an effective chemotherapeutic agent against breast cancer in mice.
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