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AD182706 - 4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a

AD182706

4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a

4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyce... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[71831-09-9]
Synonyms
Avermectin B1a?monosaccharide
Product Code
AD182706
MOL file
Chemical Formula
C41H60O11
Molecular Weight
728.91 g/mol
Smiles
O[C@]/12[C@@]3(OC\C1=C/C=C/[C@H](C)[C@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)\C(\C)=C\C[C@@]5(C[C@](OC(=O)[C@@]2(C=C(C)[C@H]3O)[H])(C[C@]6(O5)O[C@]([C@H](CC)C)([C@@H](C)C=C6)[H])[H])[H])[H]
Long Term Storage
store at <-15°C, close container well
Storage
store at <-15°C, close container well
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29329900 - USA: 2932999090 - Slovakia: 2932990090 - UK: 2932990090 - China: 2932209090
4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a is a semi-synthetic derivative of avermectin, which is a naturally occurring compound isolated from the fermentation broth of the soil bacterium *Streptomyces avermitilis*. This compound exhibits potent antiparasitic activity by targeting the glutamate-gated chloride channels in the nervous systems of parasitic organisms. By binding and activating these channels, it increases the permeability of the cell membrane to chloride ions, resulting in paralysis and death of the parasite.

The compound is primarily used to control a variety of parasitic worms and arthropods in both agricultural and veterinary contexts. Its specificity for invertebrate nerve cells over those of vertebrates makes it particularly effective with minimal toxicity to the host species. This precision in action helps maintain ecological balance while preserving host health. It is a critical tool in managing parasitic resistance, providing a reliable option for controlling infestations that are prone to adapt to other treatment strategies.
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Specification
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MSDS
TSE / BSE Statement
TSE-BSE declaration 4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a AD182706
Retest Statement
Retest Statement 4′-O-De(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)-5-O-demethylavermectin A1a AD182706
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