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FH00585 - 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

FH00585

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine

1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine (1APHP) is a potential antiviral drug. It has been shown to bind to viral proteins and inhibit the release of viral particles. 1APHP binds to the active site of the helicase-primase enzyme that is ... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[74853-08-0]
Product Code
FH00585
MDL No
MFCD02093082
MOL file
Chemical Formula
C16H19N3O
Molecular Weight
269.34 g/mol
Smiles
C1CN(CCN1C2=CC=C(C=C2)N)C3=CC=C(C=C3)O
1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine (1APHP) is a potential antiviral drug. It has been shown to bind to viral proteins and inhibit the release of viral particles. 1APHP binds to the active site of the helicase-primase enzyme that is necessary for viral replication, thereby preventing the synthesis of new DNA. 1APHP has been shown to exhibit anticancer activity in animal cancer cell lines and in bone cancer cells. 1APHP inhibits cancer cell growth by inducing apoptosis via a multistep process that includes inhibition of protein synthesis, induction of endoplasmic reticulum stress, and activation of caspases. The crystal structure and diffraction data have been elucidated using X-ray crystallography and X-ray diffraction respectively. Molecular docking studies were performed with HIV protease as a model system to study possible interactions between 1APHP and HIV protease.
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TSE / BSE Statement
TSE-BSE declaration 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine FH00585
Retest Statement
Retest Statement 1-(4-Aminophenyl)-4-(4-hydroxyphenyl)piperazine FH00585
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