FP111505

Z-Phe-Pro-OH

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Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No

[7669-64-9]

Product Code

FP111505

MDL No

MFCD00037337

MOL file

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Chemical Formula

C₂₂H₂₄N₂O₅

Molecular Weight

396.44 g/mol

Smiles

C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3)C(=O)O

Z-Phe-Pro-OH is a pentafluorophenyl activated solvent. It is an amino acid with a hydrophobic side chain that is able to form amide bonds with nucleophiles such as the chloroformate in the presence of catalytic amounts of sodium methoxide. This reaction yields the product in high yield and purity, while having little to no effect on other amino acids present. Z-Phe-Pro-OH can also be used as a transpeptidase catalyst, which is an enzyme that catalyzes the formation of peptide bonds between two amino acids. The mutant sequence of this enzyme can be isolated by chloroformate mutagenesis, which can then be purified by crystallization techniques.

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Specification

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MSDS

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TSE / BSE Statement

TSE-BSE declaration Z-Phe-Pro-OH FP111505

Retest Statement

Retest Statement Z-Phe-Pro-OH FP111505

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peptide, synthesis, coupling, amino, amino acid, peptides, amides, peptide synthesis, acid amides, enzyme, solution, bovine, agents, agent, pentafluorophenyl, yield, method, endopeptidase, aminolysis, enzymatic, catalyzed, amino acids, racemization, studies, esters, protein, solution phase, efficient, microwave, Show more,

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