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ND09159 - 2'-Deoxy-5'-O-DMT-N6-methyladenosine

ND09159

2'-Deoxy-5'-O-DMT-N6-methyladenosine

2'-Deoxy-5'-O-DMT-N6-methyladenosine is a mutant of the natural nucleoside adenosine which has been synthesized as a model for the study of the enzyme ribonucleotide reductase. The mutant has a frameshift mutation, and the resulting protein is u... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

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CAS No
[98056-69-0]
Synonyms
2'-Deoxy-5'-O-DMT-N6-methyl-D-adenosine
5'-O-DMT-N6-methyl-2'-deoxyadenosine
Product Code
ND09159
MDL No
MFCD00079127
MOL file
Chemical Formula
C32H33N5O5
Molecular Weight
567.64 g/mol
Smiles
CNC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O
Long Term Storage
store at 2°C - 8°C, close container well
Storage
store at 2°C - 8°C, close container well
Hazard Statement Code
H315, H319, H350, H335
Precautionary Statement Code
P201, P280, P302+P352, P304+P340, P305+P351+P338, P403+P233, P501
GHS Information
GHS Code GHS07GHS Code GHS08
Harmonized Tariff Codes
Switzerland: 29349999 - USA: 2934920000 - Slovakia: 2934999090 - UK: 2934999090 - China: 2934999099
2'-Deoxy-5'-O-DMT-N6-methyladenosine is a mutant of the natural nucleoside adenosine which has been synthesized as a model for the study of the enzyme ribonucleotide reductase. The mutant has a frameshift mutation, and the resulting protein is unable to catalyze DNA synthesis. It can be complemented by adding wild type nucleotides to regenerate the original sequence. 2'-Deoxy-5'-O-DMT-N6-methyladenosine inhibits the synthetase activity of ribonucleotide reductase and also inhibits polymerization of erythromycin B and styrene. 2'-Deoxy-5'-O-DMT-N6-methyladenosine has been shown to inhibit dehydrogenase activity in auxotrophs of Escherichia coli.
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ND09159 CofA
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