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CRB1000016 - Histatin-5

CRB1000016

Histatin-5

Histatins are histidine rich cationic peptides produced in salivary glands and released into the saliva. The main histatins that make up more than 80% of histatins in saliva are histatin 1, histatin 3 and histatin 5. There are two histatin genes... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

Update on Shipping Rates — Effective May, 2026
Synonyms
H-DSHAKRHHGYKRKFHEKHHSHRGY-OH
DSHAKRHHGYKRKFHEKHHSHRGY-acid
H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-Hi s-His-Ser-His-Arg-Gly-Tyr-
Product Code
CRB1000016
Molecular Weight
3,036.29 g/mol
Long Term Storage
store at <-15°C
Storage
store at <-15°C
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29337900 - USA: 2933798500 - Slovakia: 2933790090 - UK: 2933790090 - China: 2933790099
Histatins are histidine rich cationic peptides produced in salivary glands and released into the saliva. The main histatins that make up more than 80% of histatins in saliva are histatin 1, histatin 3 and histatin 5. There are two histatin genes, one which encodes histatin 1, and one that encodes histatin 3, all other histatins are derivatives of these two histatins. Histatin 3 is a precursor of histatin 5, each with distinct roles.
Histatin 5??is considered an antimicrobial peptide (AMP) as it has antibacterial activity as has been shown against opportunist infections such as P. aeruginosa, E. coli, and S. aureus. Histatin 5 also has potent anticandidal activity for example against Candida and Leishmania, it is shown to be the strongest antifungal of the histatins. ?The antifungal activity functions by invasion of the microbe and entry to the mitochondria, histatin 5 then inhibits ATPase activity resulting in rapid depletion and ultimately bacterial cell death/apoptosis. As a salivary peptide, it inhibits Bacteroides gingivalis proteinase?clostripain and protease activity microbe implicated in periodontal disease.
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CoA (Example)
CRB1000016 CofA
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