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CRB1000022 - Indolicidin

CRB1000022

Indolicidin

Indolicidin is a natural cationic cathelicidin family anti-microbial peptide (AMP) with a very wide killing spectrum which includes: Gram-positive and Gram-negative bacteria, fungi, protozoa and HIV. ?It is also an immune system modulator and a... Read More
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  Strictly for Research Purposes only. Not for Personal or Veterinary use.

Update on Shipping Rates — Effective May, 2026
Synonyms
H-ILPWKWPWWPWRR-NH2
Product Code
CRB1000022
Molecular Weight
1,906.28 g/mol
Long Term Storage
store at <-15°C
Storage
store at <-15°C
Precautionary Statement Code
P261, P262
Harmonized Tariff Codes
Switzerland: 29337900 - USA: 2933798500 - Slovakia: 2933790090 - UK: 2933790090 - China: 2933790099
Indolicidin is a natural cationic cathelicidin family anti-microbial peptide (AMP) with a very wide killing spectrum which includes: Gram-positive and Gram-negative bacteria, fungi, protozoa and HIV. ?It is also an immune system modulator and an inhibitor of aminoglycoside antibiotic-resistance enzymes.
Indolicidin contains 5 tryptophan residues (39% of peptide content)- the highest tryptophan proportion ever seen in a peptide or protein.
When indolicidin interacts with biological membranes it assumes a wedge- shaped conformation, with the hydrophobic tryptophan residues in the trough of the wedge, and positively charged regions flanking them at each end. If fully extended, indolicidin is able to span both lipid bilayers despite only consisting of 13 amino acid residues. This is possible because indolicidin adopts an approximate poly-l-proline type II helix conformation, which is characterized by very high helical pitches.
The exact mode of action of indolicidin is still unknown. At bactericidal concentrations the peptide appears to translocate through the membrane into the cytosol where it may bind to nucleic acids, whereas at higher concentrations it is membranolytic.
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CoA (Example)
CRB1000022 CofA
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