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CRB1001289 - AF12198

CRB1001289

AF12198

AF12198 is a selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1) and thus blocks IL-1β signalling. AF12198 can inhibit IL-1-induced IL-8 production by human dermal fibroblasts and IL-1-induced intercellular adhesion... Read More
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There is no hazardous surcharge associated with this product

There is no packaging charge associated with this product

  Strictly for Research Purposes only. Not for Personal or Veterinary use.

Update on Shipping Rates — Effective May, 2026
Synonyms
Ac-FEWTPGWYQJYALPL-NH2, J is L-azetidine-2-carboxylic acid
Ac-FEWTPGWYQJYALPL-amide
Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-J-Tyr-Ala -Leu-Pro-Leu-NH2
CS1
IL-1ra
Ac-FEWTPGWYQXYALPL-amide
Product Code
CRB1001289
Molecular Weight
1,895.9 g/mol
Long Term Storage
store at <-15°C
Storage
store at <-15°C
Harmonized Tariff Codes
Switzerland: 29337900 - USA: 2933798500 - Slovakia: 2933790090 - UK: 2933790090 - China: 2933790099
AF12198 is a selective receptor antagonist to the human cytokine, type 1 interleukin-1 (IL-1) and thus blocks IL-1β signalling. AF12198 can inhibit IL-1-induced IL-8 production by human dermal fibroblasts and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells. AF12198 also blocks IL-1 induction of IL-6 and down regulates IL-6 induction in monkeys. AF12198 does not bind the human type II IL-1 receptor, or the murine type I IL-1 receptor.
IL-1 influences a wide range of immune and inflammatory responses. Sustained expression of even low levels of IL-1 can be harmful in chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
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Specification
English
CoA (Example)
CRB1001289 CofA
MSDS
Request MSDS
TSE / BSE Statement
TSE-BSE declaration AF12198 CRB1001289
Retest Statement
Retest Statement AF12198 CRB1001289
CoA (Example)
CRB1001289 CofA
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