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Corr4A

  Cat. No.:  DC12003   Featured
Chemical Structure
421580-53-2
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More than 5000 active chemicals with high quality for research!
Field of application
A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..
Cas No.: 421580-53-2
Chemical Name: N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide
Synonyms: ST075396; MLS000561131; Corr-4a; Oprea1_189688; Oprea1_471654; CHEMBL260775; MolPort-001-986-142; ZINC00888741; AKOS001665304;
SMILES: COC1=C(C=C(Cl)C=C1)NC2=NC(=CS2)C3=C(C)N=C(NC(=O)C4=CC=CC=C4)S3
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM.
Cat. No. Product name Field of application
DC72875 GLPG2451 GLPG2451 (GLPG 2451) is a potent potentiator of cystic fibrosis transmembrane conductance regulator (CFTR) with EC50 of 11 nM for F508del CFTR in the YHA assay and EC50 of 18 nM in TECC assay using HBE cells from patients carrying the F508del mutation. GLPG2451 improves the gating function of the CFTR channel.
DC70796 SRI-41315 SRI-41315 is a small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion, restores CFTR expression and function, suppresses CFTR nonsense mutations.SRI-41315 induces translational readthrough by depleting eRF1 protein level and prolonging the translational pause that occurs at premature termination codons (PTCs).SRI-41315 reduced eRF1 levels in a manner dependent upon a ubiquitin-mediated proteasome degradation pathway.SRI-41315 in combination with G418 restores CFTR function in primary bronchial epithelial cells derived from a CF patient with CFTR nonsense alleles.
DC48190 Vanzacaftor Vanzacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) for treating cystic fibrosis.
DC11678 Galicaftor Galicaftor (ABBV-2222/GLPG-2222) is an orally bioavailable small molecule that functions as a CFTR corrector, demonstrating potential for therapeutic development in cystic fibrosis research.
DC12003 Corr4A A small molecule corrector of ΔF508-CFTR with IC50 of 6.0 uM..
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