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  2. Cell Cycle/DNA Damage Apoptosis
  3. CDK Apoptosis
  4. Aminopurvalanol A

Aminopurvalanol A 是一種有效的、選擇性的、可滲透細(xì)胞的 Cyclins/Cdk 復(fù)合物抑制劑。Aminopurvalanol A 優(yōu)先靶向G2/M 期轉(zhuǎn)變進(jìn)而抑制癌細(xì)胞分化。Aminopurvalanol A 通過抑制生理獲能依賴性肌動(dòng)蛋白聚合而抑制精子受精能力。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報(bào)，我們不為任何個(gè)人用途提供產(chǎn)品和服務(wù)

Aminopurvalanol A

Aminopurvalanol A Chemical Structure

CAS No. : 220792-57-4

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規(guī)格 價(jià)格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥1320
In-stock
1 mg ￥480
In-stock
5 mg ￥1200
In-stock
10 mg ￥2000
In-stock
25 mg ￥3900
In-stock
50 mg ￥6000
In-stock
100 mg 現(xiàn)貨 詢價(jià)
200 mg   詢價(jià)  
500 mg   詢價(jià)  

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Customer Review

Other Forms of Aminopurvalanol A:

MCE 顧客使用本產(chǎn)品發(fā)表的 1 篇科研文獻(xiàn)

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].

IC50 & Target

Cyclins/Cdk[1]
細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
KM12 GI50
30 nM
Compound: K00613a, Aminopurvalanol
Inhibition of human KM12 cells
Inhibition of human KM12 cells
[PMID: 18077363]
Oocyte IC50
33 nM
Compound: 97
In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
[PMID: 10753466]
Oocyte IC50
35 nM
Compound: 97
In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
In vitro inhibitory activity against Cyclin-dependent kinase 1-cyclin B complex from starfish oocytes
[PMID: 10753466]
體外研究
(In Vitro)

Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[2]

Cell Line: Human U937 leukemic cells
Concentration: 5 and 40 μM
Incubation Time: 8 hours
Result: Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations.

Apoptosis Analysis[2]

Cell Line: Human U937 leukemic cells
Concentration: 5 and 40 μM
Incubation Time: 8 hours
Result: 40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.
分子量

403.91

Formula

C19H26ClN7O
CAS 號(hào)
性狀

固體

顏色

Off-white to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn)： 

DMSO 中的溶解度 : 100 mg/mL (247.58 mM; 超聲助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

配制儲(chǔ)備液
濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
1 mM 2.4758 mL 12.3790 mL 24.7580 mL
5 mM 0.4952 mL 2.4758 mL 4.9516 mL
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