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  2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (rel)-Asperparaline A

(rel)-Asperparaline A ((rel)-Aspergillimide)，是一種從 Aspergillus japonicas JV-23 發(fā)酵的豆渣中分離得到的驅(qū)蟲代謝產(chǎn)物。(rel)-Asperparaline A 也是一種有效和選擇性的 nAChR 拮抗劑。(rel)-Asperparaline A 在蠶中表現(xiàn)出麻痹作用。

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(rel)-Asperparaline A

(rel)-Asperparaline A Chemical Structure

CAS No. : 195966-93-9

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規(guī)格 價格 是否有貨 數(shù)量
5 mg ￥8748
3 - 4 周
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms[1][2].

體外研究
(In Vitro)

Asperparaline A (1 μM; 1 min) markedly and reversibly blocks the acetylcholine (Ach; 10 μM)-induced current in the silkworm larval neurons[2].
Asperparaline A (1-1000 nM; 1 min) differentially blocks the peak and slowly desensitizing currents, with IC50s of 20.2 and 39.6 nM, respectively[2].
Asperparaline A (10 μM; 1 min) reduces the peak current amplitude of the ACh (100 μM)-induced response of α3β4 nAChR by 33.4%, while barely influencing the amplitudes of the responses to ACh of the α4β2 and α7 nAChRs in X. laevis oocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Asperparaline A (10 μg/g; p.o.) exhibits paralysis against silk worms within 1 h and lasts for 7 to 10 h[1].
Asperparaline A (3 μg/g; injection with a micro-syringe) exhibits paralysis activity against silk worms within 20 min and lasts for 4 to 5 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

359.46

Formula

C20H29N3O3
CAS 號
結(jié)構(gòu)分類
初始來源

Aspergillus japonicus JV-23
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

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產(chǎn)品名稱：
(rel)-Asperparaline A
目錄號：
HY-124874
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