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  1. Others Anti-infection
  2. Antibiotic Fungal Environmental Pollutants Bacterial
  3. Fluconazole

Fluconazole (UK-49858) 是一種三唑類抗真菌劑 (antifungal),對多種真菌具有優(yōu)異的活性,尤其對Candida albicans,F(xiàn)luconazole 抑制C. albicansCandida kefyr 的 IC99 為 0.20 μg/mL 至 0.39 μg/mL。

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CAS No. : 86386-73-4

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10 mM * 1 mL in DMSO ¥715
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100 mg ¥650
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500 mg ¥1500
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5 g   詢價  

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Customer Review

Other Forms of Fluconazole:

    Fluconazole purchased from MCE. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171.  [Abstract]

    Fungal burden of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

    Fluconazole purchased from MCE. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171.  [Abstract]

    Weight loss of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

    Fluconazole purchased from MCE. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171.  [Abstract]

    Colon length of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

    Fluconazole purchased from MCE. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171.  [Abstract]

    Histological analysis of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

    Fluconazole purchased from MCE. Usage Cited in: Microb Biotechnol. 2022 Feb;15(2):482-498.  [Abstract]

    Candida albicans (SC5314) was placed in YPD medium and serially diluted with fluconazole, panatinib, or both. OD600 values were measured every 15 minutes at 30°C, and FICI values were calculated according to the CLSI Broth Microdilution Reference Guide (M38-A)
    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    生物活性

    Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1].

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    16HBE14o- CC50
    > 1000 μg/mL
    Compound: FLC
    Cytotoxicity against human 16HBE by MTS assay
    Cytotoxicity against human 16HBE by MTS assay
    [PMID: 34998904]
    A549 EC50
    > 62.5 μg/mL
    Compound: FLC
    Toxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
    Toxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
    [PMID: 28395217]
    A549 IC50
    > 100 μg/mL
    Compound: FCZ
    Cytotoxicity against human A549 cells by MTT assay
    Cytotoxicity against human A549 cells by MTT assay
    [PMID: 30318439]
    A549 IC50
    > 30 μM
    Compound: FLC
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 96 hrs by MTT assay
    [PMID: 34388384]
    A549 IC50
    > 50 μM
    Compound: 1; FLC, FCZ
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    [PMID: 34749201]
    A549 IC50
    > 50 μM
    Compound: FLC
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
    Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
    [PMID: 35255313]
    BEAS-2B EC50
    > 62.5 μg/mL
    Compound: FLC
    Toxicity in human BEAS2B cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
    Toxicity in human BEAS2B cells assessed as reduction in cell viability incubated for 24 hrs by resazurin dye based assay
    [PMID: 28395217]
    Caco-2 IC50
    > 64 μg/mL
    Compound: FLC
    Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
    Cytotoxicity against human Caco-2 cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
    [PMID: 37975824]
    H9c2 IC50
    > 100 μg/mL
    Compound: FCZ
    Cytotoxicity against rat H9c2 cells by MTT assay
    Cytotoxicity against rat H9c2 cells by MTT assay
    [PMID: 30318439]
    HEK-293T IC50
    > 50 μM
    Compound: 1; FLC, FCZ
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    Cytotoxicity against human HEK293T cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    [PMID: 34749201]
    HEK293 IC50
    > 250 μM
    Compound: Fluconazole
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    Cytotoxicity against human HEK293 cells after 72 hrs by MTT assay
    [PMID: 29626797]
    HL-60 IC50
    11.6 μM
    Compound: Fluconazole
    Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
    Cytotoxicity against human HL-60 cells assessed as inhibition of cell growth by MTT assay
    [PMID: 36336315]
    HT-29 IC50
    > 100 μg/mL
    Compound: FCZ
    Cytotoxicity against human HT-29 cells by MTT assay
    Cytotoxicity against human HT-29 cells by MTT assay
    [PMID: 30318439]
    HUVEC IC50
    9.177 μg/mL
    Compound: FLC
    Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
    Cytotoxicity against HUVEC cells assessed as cell growth inhibition incubated for 24 hrs by CCK8 assay
    [PMID: 37975824]
    HUVEC IC50
    > 40 μM
    Compound: FLC
    Inhibition of HDAC in HUVEC using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry
    Inhibition of HDAC in HUVEC using Boc-Lys(Ac)-AMC as substrate preincubated for 12 hrs followed by substrate addition and measured after 4 hrs by fluorimetry
    [PMID: 32347094]
    HUVEC IC50
    > 64 μg/mL
    Compound: FLC
    Cytotoxicity against human HUVEC cells assessed as inhibition on cell growth incubated for 24 hrs by CCK-8 assay
    Cytotoxicity against human HUVEC cells assessed as inhibition on cell growth incubated for 24 hrs by CCK-8 assay
    [PMID: 35922963]
    HeLa IC50
    > 100 μg/mL
    Compound: Fluconazole
    Cytotoxicity against human HeLa cells after 48 hrs by SRB assay
    Cytotoxicity against human HeLa cells after 48 hrs by SRB assay
    [PMID: 26848627]
    HepG2 CC50
    > 128 μg/L
    Compound: FLC
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by XTT assay
    [PMID: 33335669]
    HepG2 IC50
    > 100 μg/mL
    Compound: FCZ
    Cytotoxicity against human HepG2 cells by MTT assay
    Cytotoxicity against human HepG2 cells by MTT assay
    [PMID: 30318439]
    HepG2 IC50
    > 250 μg/mL
    Compound: Fluconazole
    Cytotoxicity against human HepG2 cells after 2 days by MTT assay
    Cytotoxicity against human HepG2 cells after 2 days by MTT assay
    [PMID: 25740636]
    HepG2 IC50
    > 300 μM
    Compound: FLU
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTS assay
    [PMID: 24953953]
    HepG2 IC50
    > 50 μM
    Compound: 1; FLC, FCZ
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth incubated for 4 hrs by MTT assay
    [PMID: 34749201]
    HepG2 IC50
    > 50 μM
    Compound: FLC
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
    Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 96 hrs by MTT assay
    [PMID: 35255313]
    K562 CC50
    385.2 μM
    Compound: 5
    Cytotoxicity to reduce chronic myeloid leukemia K 562 cells
    Cytotoxicity to reduce chronic myeloid leukemia K 562 cells
    [PMID: 15267229]
    K562 CC50
    385.2 μM
    Compound: 5, fluconazole
    Cytotoxicity against human K562 cells after assessed as reduction of cell viability 24 hrs by MTT assay
    Cytotoxicity against human K562 cells after assessed as reduction of cell viability 24 hrs by MTT assay
    [PMID: 18529046]
    L6 IC50
    9.967 μM
    Compound: fluconazole
    Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells assessed as parasite growth inhibition after 96 hrs by colorimetric analysis
    Antitrypanosomal activity against amastigote stage of Trypanosoma cruzi Tulahuen C4 infected in rat L6 cells assessed as parasite growth inhibition after 96 hr 定安县| 济阳县| 淄博市| 兰坪| 长汀县| 柘城县| 湛江市| 桂阳县| 福贡县| 达孜县| 平顶山市| 桂林市| 龙门县| 台安县| 西和县| 汝城县| 霍州市| 文昌市| 宁夏| 彩票| 乐山市| 塘沽区| 濮阳县| 宣化县| 武平县| 马山县| 永德县| 二手房| 方正县| 广安市| 吴堡县| 两当县| 闻喜县| 新民市| 塔河县| 浙江省| 烟台市| 资兴市| 竹溪县| 古田县| 兴国县|