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  2. Autophagy
  3. Autophagy
  4. Trimetazidine

Trimetazidine 是一種選擇性的長鏈 3-ketoyl coenzyme A thiolase 抑制劑，IC50 值為 75 nM，可抑制游離脂肪酸的 β-氧化。Trimetazidine 是一種有效的抗心絞痛劑和一種細(xì)胞保護(hù)劑，具有抗氧化，抗炎，抗傷害和胃保護(hù)作用。Trimetazidine 誘導(dǎo)自噬 (autophagy)，還是一種 HADHA 抑制劑。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

CAS No. : 5011-34-7

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     可免費(fèi)申領(lǐng)三個不同產(chǎn)品的試用裝。

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規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥343
In-stock
1 mg ￥156
In-stock
5 mg ￥312
In-stock
10 mg ￥500
In-stock
50 mg ￥800
In-stock
100 mg   詢價  
200 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Trimetazidine:

    Trimetazidine purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2026 Jan 21:e17054.

    Colony formation assays evaluated the proliferative capacity of MASH‐HCC cells (PA/OA and IL-6/TNF-α/LPS-treated HuH‐7 cells) and non-MASH-HCC cells transfected with vector or OCTN2, with or without Trimetazidine (TMZ) (1 mM).

    Trimetazidine purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2026 Jan 21:e17054.

    The FAO inhibitor Trimetazidine (TMZ) (1 mM) abrogated the enhanced migration and invasion of non-MASH-HCC cells caused by OCTN2 overexpression.

    Trimetazidine purchased from MCE. Usage Cited in: Adv Sci (Weinh). 2026 Jan 21:e17054.

    Wound healing assays evaluated the migration ability of MASH-HCC and non-MASH-HCC cells transfected with vector or OCTN2, with or without Trimetazidine (TMZ) (1 mM) treatment.

    Trimetazidine purchased from MCE. Usage Cited in: J Adv Res. 2025 Mar 17:S2090-1232(25)00186-9.  [Abstract]

    OVCAR8-Persister and A2780-Persister cells were pretreated with vehicle or Trimetazidine (TMZ) (100 μM; 24 h) and subsequently treated with various concentrations of paclitaxel (1-1×104 nM; 48 h), after which cell viability was assessed using a CCK-8 assay.

    Trimetazidine purchased from MCE. Usage Cited in: J Adv Res. 2025 Mar 17:S2090-1232(25)00186-9.  [Abstract]

    Trimetazidine (TMZ) (100 μM; 24 h) pretreatment increased the sensitivity of OVCAR8-Persister and A2780-Persister cells to paclitaxel.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻(xiàn)

    生物活性

    Trimetazidine is a selective long chain 3-ketoyl coenzyme A thiolase inhibitor with an IC50 of 75 nM, which can inhibit β-oxidation of free fatty acid (FFA). Trimetazidine is an effective antianginal agent and a cytoprotective agent, has anti-oxidant, anti-inflammatory, antinociceptive and gastroprotective properties. Trimetazidine triggers autophagy. Trimetazidine is also a 3-hydroxyacyl-CoA dehydrogenase (HADHA) inhibitor[1][2][3][4].

    IC50 & Target

    IC50: 75 nM (long chain 3-ketoyl coenzyme A thiolase)[2]
    β-oxidation[2]
    Autophagy[3]
    3-hydroxyacyl-CoA dehydrogenase (HADHA)[4]
    細(xì)胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    KB IC50
    47.1 μM
    Compound: 43
    Cytotoxicity in human KB cells
    Cytotoxicity in human KB cells
    		[PMID: 21504156]
    體外研究
    (In Vitro)

    Trimetazidine (1-100 μM；24 h；HUVECs) 以一定的劑量依賴方式增強(qiáng)氧化誘導(dǎo)損傷的 HUVECs 的活力[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Human umbilical vein endothelial cells (HUVECs)
    Concentration: 1 μM,10 μM,100 μM
    Incubation Time: 24 hours
    Result: Enhanced the viability of the injured HUVECs induced by oxidation.
    體內(nèi)研究
    (In Vivo)

    Trimetazidine (5 -20 mg/kg；口服給藥；1 小時；瑞士白化雄性小鼠) 以 10 和 20 mg/kg 的劑量顯著提高小鼠 ICES 試驗(yàn)中的癲癇發(fā)作閾值電流[5]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Swiss albino male mice (24-35 g)[4]
    Dosage: 5 mg/kg, 10 mg/kg and 20 mg/kg;
    10 mL/kg body weight
    Administration: Oral administration ; 1 hour
    Result: In 10 and 20mg/kg doses significantly raised the seizure-threshold current in the ICES test.
    分子量

    266.34

    Formula

    C14H22N2O3
    CAS 號
    性狀

    油狀物

    顏色

    White to off-white

    中文名稱

    曲美他嗪
    運(yùn)輸條件

    Room temperature in continental US; may vary elsewhere.
    儲存方式

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    溶解性數(shù)據(jù)
    細(xì)胞實(shí)驗(yàn)： 

    DMSO 中的溶解度 : 116.67 mg/mL (438.05 mM; 超聲助溶 (<60°C); 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

    配制儲備液
    濃度 溶劑體積 質(zhì)量 1 mg 5 mg 10 mg
    1 mM 3.7546 mL 18.7730 mL 37.5460 mL
    5 mM 0.7509 mL 3.7546 mL 7.5092 mL
    查看完整儲備液配制表

    * 請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；一旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。
    儲備液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C儲存時，請在6個月內(nèi)使用，-20°C儲存時，請在1個月內(nèi)使用。

    • 摩爾計算器

    • 稀釋計算器

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