一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

  2. Anti-infection Cell Cycle/DNA Damage Apoptosis
  3. Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
  4. Cynaroside

Cynaroside  (Synonyms: 木犀草苷; Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside)

目錄號: HY-N0540
一鍵復(fù)制產(chǎn)品信息 純度: 99.37%
COA 產(chǎn)品使用指南 技術(shù)支持

Cynaroside (Luteolin 7-glucoside) 是一種具有抗氧化能力的黃酮類化合物。Cynaroside 還是一種流感依賴的 RNA 聚合酶 抑制劑，IC50 為 32 nM。Cynaroside 也是一種應(yīng)對 2O2 誘導(dǎo)的細胞凋亡的抑制劑，對氧化應(yīng)激誘導(dǎo)的心血管疾病具有細胞保護作用。Cynaroside 還具有抗細菌、真菌和抗癌活性，以及抗氧化和抗炎活性。

MCE 的所有產(chǎn)品僅用作科學(xué)研究或藥證申報，我們不為任何個人用途提供產(chǎn)品和服務(wù)

CAS No. : 5373-11-5

1.  客戶無需承擔(dān)相應(yīng)的運輸費用。

2.  同一機構(gòu)（單位）同一產(chǎn)品試用裝僅限申領(lǐng)一次，同一機構(gòu)（單位）一年內(nèi)

     可免費申領(lǐng)三個不同產(chǎn)品的試用裝。

3.  試用裝只面向終端客戶。

規(guī)格 價格 是否有貨 數(shù)量
10 mM * 1 mL in DMSO ￥836
In-stock
1 mg ￥380
In-stock
5 mg ￥760
In-stock
10 mg ￥1140
In-stock
25 mg ￥1990
In-stock
50 mg ￥3180
In-stock
100 mg ￥4800
In-stock
200 mg   詢價  
500 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of Cynaroside:

    Cynaroside purchased from MCE. Usage Cited in: Eur J Pharmacol. 2025 Sep 24:178196.  [Abstract]

    RAW 264.7 cells were treated with Cynaroside at the indicated concentrations. After 24 h of incubation, cell viability was assessed using the MTT assay.

    Cynaroside purchased from MCE. Usage Cited in: Eur J Pharmacol. 2025 Sep 24:178196.  [Abstract]

    RAW 264.7 cells were treated with Cynaroside (10 or 100 μM) for 30 min before they were treated with GrB (25 nM) and perforin (1 nM) for 24 h. Cleaved caspase-3 protein was detected by Western blotting.

    Cynaroside purchased from MCE. Usage Cited in: Eur J Pharmacol. 2025 Sep 24:178196.  [Abstract]

    Human plasma fibronectin was incubated with GrB and either Cynaroside (10 or 100 μM) or IEPD (100 μM) in vitro, and the results were visualized by Western blotting.

    Cynaroside purchased from MCE. Usage Cited in: Eur J Pharmacol. 2025 Sep 24:178196.  [Abstract]

    MCF-7 cells were plated on fibronectin-coated Transwell plates in serum-free DMEM and allowed to migrate toward 5 % FBS for 24 h in the presence of the indicated concentrations of Cynaroside (10 or 100 μM) and GrB (25 nM). The cells on the underside of the membrane were stained with 0.5 % crystal violet.

    Cynaroside purchased from MCE. Usage Cited in: Eur J Pharmacol. 2025 Sep 24:178196.  [Abstract]

    Cynaroside (10 mg/kg). The expression levels of TSLP and IL-6 mRNA in ear skin tissue on day 26 were detected by qRT-PCR.

    • 生物活性

    • 純度 & 產(chǎn)品資料

    • 參考文獻

    恩平市| 友谊县| 平度市| 巴青县| 息烽县| 乳源| 临潭县| 青州市| 淳安县| 三穗县| 神农架林区| 卢氏县| 沂水县| 新营市| 松江区| 年辖：市辖区| 柞水县| 波密县| 兴文县| 沙洋县| 靖边县| 安塞县| 盐源县| 新龙县| 松潘县| 武夷山市| 武义县| 西城区| 东兴市| 望城县| 景宁| 眉山市| 平陆县| 泸水县| 綦江县| 肥乡县| 上蔡县| 安泽县| 舞钢市| 麻栗坡县| 乌海市|
    生物活性

    Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 32 nM. Cynaroside also is a promising inhibitor for H2O2-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities[1][3][4][5].

    IC50 & Target

    RNA Polymerase

     

    細胞效力
    (Cellular Effect)
    Cell Line Type Value Description References
    B16-4A5 IC50
    > 100 μM
    Compound: 6
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis
    Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs by microplate reader analysis
    		[PMID: 25987378]
    CCRF-CEM IC50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human CEM cells after 3 days by MTT assay
    Cytotoxicity against human CEM cells after 3 days by MTT assay
    		[PMID: 11421746]
    H9 EC50
    7 μM
    Compound: 6
    Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral replication after 3 days by p24 antigen capture assay
    		[PMID: 8158164]
    H9 IC50
    25 μM
    Compound: 6
    Cytotoxicity against human H9 cells after 3 days
    Cytotoxicity against human H9 cells after 3 days
    		[PMID: 8158164]
    H9c2 EC50
    5.04 μM
    Compound: 7
    Cytoprotective activity against doxorubicin-induced cytotoxicity in rat H9c2 cells assessed as cell viability after 24 hrs by MTT assay
    Cytoprotective activity against doxorubicin-induced cytotoxicity in rat H9c2 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 20932762]
    HL-60 IC50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human HL60 cells after 3 days by MTT assay
    Cytotoxicity against human HL60 cells after 3 days by MTT assay
    		[PMID: 11421746]
    HeLa S3 IC50
    > 10 μM
    Compound: 13
    Cytotoxicity against human HeLa S3 cells assessed as cell viability incubated for 48 hrs by microscopic analysis
    Cytotoxicity against human HeLa S3 cells assessed as cell viability incubated for 48 hrs by microscopic analysis
    		[PMID: 35704432]
    HepG2 IC50
    20.8 μM
    Compound: 6
    Anticancer activity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
    Anticancer activity against human HepG2 cells assessed as cell viability after 24 hrs by MTT assay
    		[PMID: 24974349]
    Huh-7 CC50
    > 50 μM
    Compound: 9
    Cytotoxicity against human Huh7.5.1 cells by MTT assay
    Cytotoxicity against human Huh7.5.1 cells by MTT assay
    		[PMID: 22445328]
    MDCK CC50
    > 1116 μM
    Compound: 5
    Cytotoxicity against MDCK cells by MTT assay
    Cytotoxicity against MDCK cells by MTT assay
    		[PMID: 18640042]
    MDCK CC50
    > 446 μM
    Compound: Luteolin-7-glucoside
    Cytotoxicity against MDCK cells
    Cytotoxicity against MDCK cells
    		[PMID: 25096296]
    RAW264.7 CC50
    > 100 μM
    Compound: 20
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
    		[PMID: 33667099]
    RAW264.7 IC50
    6.1 μM
    Compound: 9
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as decrease in PGE2 production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
    Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as decrease in PGE2 production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA
    		[PMID: 31747281]
    RAW264.7 IC50
    8.3 μM
    Compound: 13
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method
    		[PMID: 25176187]
    RAW264.7 IC50
    87.5 μM
    Compound: 20
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay
    		[PMID: 33667099]
    RAW264.7 IC50
    > 20 μM
    Compound: luteolin-7-O-beta-D-glucopyranoside
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
    Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitrite accumulation after 24 hrs by Griess reagent method
    		[PMID: 19778086]
    RD EC50
    0.43 mM
    Compound: Luteoloside
    Antiviral activity against EV71 infected in human RD cells assessed as protection against virus-induced cytopathic effect after 48 hrs by MTS assay
    Antiviral activity against EV71 infected in human RD cells assessed as protection against virus-induced cytopathic effect after 48 hrs by MTS assay
    		[PMID: 27776325]
    SW1573 IC50
    > 10 μg/mL
    Compound: 10
    Cytotoxicity against human SW1573 cells after 3 days by MTT assay
    Cytotoxicity against human SW1573 cells after 3 days by MTT assay
    		[PMID: 11421746]
    體外研究
    (In Vitro)

    Cynaroside 促進巨噬細胞表型從促炎性 M1 向抗炎性 M2 轉(zhuǎn)變，并減輕膿毒癥相關(guān)的肝臟炎癥損傷。 Cynaroside 通過消除 PKM2 轉(zhuǎn)位至細胞核并促進 PKM2 四聚體形成，以及抑制 PKM2 在 Y105 位點的磷酸化，在體內(nèi)和體外減少 PKM2 與缺氧誘導(dǎo)因子-1α (HIF-1α) 的結(jié)合。 Cynaroside 恢復(fù)丙酮酸激酶活性，抑制糖酵解相關(guān)蛋白 (包括 PFKFB3、HK2 和 HIF - 1α) ，并抑制膿毒癥肝臟中 HMGB1 的糖酵解相關(guān)高乙?；? Cynaroside 通過減少 ROS 生成并抑制線粒體和死亡受體通路中的 caspase 激活，保護 H9c2 細胞免受 H2O2 誘導(dǎo)的凋亡。 Cynaroside 通過調(diào)節(jié) Bcl-2 蛋白表達以及 JNK 和 P53 表達，維持線粒體功能[2][3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Western Blot Analysis[2]

    Cell Line: RAW264.7 cell
    Concentration: 5μM, 10μM
    Incubation Time: 2 h
    Result: Reduced expression levels of IL-1β, IL-6 and TNF-α and HMGB1, suppressed M1 polarized phenotype in RAW264.7 cells.

    Immunofluorescence[2]

    Cell Line: RAW264.7 cell
    Concentration:
    Incubation Time: 4 h
    Result: Decreased PKM2 nuclear translocation in hepatic macrophages of septic mice.

    RT-PCR[2]

    Cell Line: RAW264.7 cell
    Concentration: 2.5μM, 5μM, 10μM
    Incubation Time:
    Result: Increased increased expression levels of M2 markers Arg-1, IL-10 andCD206.

    Cell Viability Assay[3]

    Cell Line: H9c2 cells
    Concentration: 25, 50, 100 μg/mL
    Incubation Time: 4 h
    Result: Protected H9c2 cells from oxidative stress-induced cell injury.

    Apoptosis Analysis[3]

    Cell Line: H9c2 cells
    Concentration: 25, 50, 100 μg/mL
    Incubation Time: 4 h
    Result: Decreased H2O2-induced apoptosis in H9C2 cells.
    體內(nèi)研究
    (In Vivo)

    Cynaroside (腹腔注射; 5 mg/kg) 通過消除 PKM2 轉(zhuǎn)位至細胞核并促進 PKM2 四聚體形成，以及抑制 PKM2 在 Y105 位點的磷酸化，減少 PKM2 與缺氧誘導(dǎo)因子-1α (HIF-1α) 的結(jié)合[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mice model of sepsis[2]
    Dosage: 5mg/kg
    Administration: Cynaroside (i.p.; 5mg/kg)
    Result: Inhibited PKM2 dimer formation in liver of septic mice.
    分子量

    448.38