β-Amyloid (1-16) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.

Amyloid-β^[1]

β-Amyloid (1-16) 片段被認(rèn)為是檢查關(guān)鍵組氨酸殘基 (小鼠中的 His、His 和人類(lèi)片段中的 His、His、His) 對(duì) Ab–Cu²⁺ 有貢獻(xiàn)的有效模型。β-Amyloid (1-16) 的氧化靶標(biāo)是與金屬離子配位的組氨酸殘基。銅與阿爾茨海默病老年斑中的 Aβ 結(jié)合，β-Amyloid (1-16) 參與 Cu²⁺離子的配位。Cu²⁺ 和 Zn²⁺ 與淀粉樣蛋白的神經(jīng)毒性和自由基損傷有關(guān)^[1]。β-Amyloid (1-16) 是最小氨基酸序列，顯示 Cu 配位模式，涉及三個(gè)組氨酸 (His6、His13 和 His14)。β-Amyloid (1-16) 應(yīng)該參與金屬結(jié)合^[2]。人 β-淀粉樣蛋白通過(guò)其金屬結(jié)合結(jié)構(gòu)域 1-16 與鋅離子相互作用。大鼠 Aβ (1-16) 二聚體的兩條多肽鏈的 C 尾方向彼此相反，這阻礙了大鼠 Aβ 二聚體組裝成寡聚體。因此，人和大鼠 β-Amyloid (1-16) 的鋅結(jié)合位點(diǎn)結(jié)構(gòu)的差異、它們形成規(guī)則交叉單體鍵的能力以及它們的疏水性 C 尾的方向可能是耐藥性的原因大鼠對(duì)阿爾茨海默病的影響^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1955.01

C₈₄H₁₁₉N₂₇O₂₈

131580-10-4

固體

White to off-white

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys

DAEFRHDSGYEVHHQK

Room temperature in continental US; may vary elsewhere.

• [1]. Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95(4):270-82.  [Content Brief]

  [2]. Minicozzi V, et al. Identifying the minimal copper- and zinc-binding site sequence in amyloid-beta peptides. J Biol Chem. 2008 Apr 18;283(16):10784-92.  [Content Brief]

  [3]. Istrate AN, et al. NMR solution structure of rat aβ(1-16): toward understanding the mechanism of rats' resistance to Alzheimer's disease. Biophys J. 2012 Jan 4;102(1):136-43.  [Content Brief]