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  2. GPCR/G Protein
  3. CaSR
  4. Etelcalcetide

Etelcalcetide (AMG 416; KAI-4169) 是一種合成的 鈣敏感受體 (CaSR) 的活化劑。Etelcalcetide 能有效降低接受血液透析的繼發(fā)性甲狀旁腺功能亢進患者的甲狀旁腺激素 (PTH) 濃度，有望用于繼發(fā)性甲狀旁腺功能亢進癥和慢性腎病領域的研究。

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Etelcalcetide

Etelcalcetide Chemical Structure

CAS No. : 1262780-97-1

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Etelcalcetide 的其他形式現(xiàn)貨產(chǎn)品:

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Other Forms of Etelcalcetide:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Etelcalcetide (AMG 416; KAI-4169) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease[1][2].
體外研究
(In Vitro)

Etelcalcetide hydrochloride (0-100 μmol/L, 2 h) 劑量依賴性降低人甲狀旁腺細胞中的甲狀旁腺激素 (PTH) 水平[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Etelcalcetide hydrochloride (2.5 μg/h 和 20 μg/h, 灌注, 3 天) 顯著降低血漿 PTH 濃度，并且在較高的流速下降低 Cyp24a1 在腎臟的表達[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL7/6J male mice
Dosage: 2.5 μg/h and 20 μg/h
Administration: infusion, 3 days
Result: Significantly reduced plasma PTH concentrations and unaltered Cldn14 expression with 2.5 μg/h, but decreased the renal expression of Cyp24a1 with 20 μg/h[1]
分子量

1048.25

Formula

C38H73N21O10S2
CAS 號
Sequence

Ac-dCys(disulfide bridge:Cys)-d(Ala-Arg-Arg-Arg-Ala-Arg)-NH2
Sequence Shortening

Ac-dCys(disulfide bridge:Cys)-d(ARRRAR)-NH2
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

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  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Etelcalcetide
目錄號：
HY-P1955
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