Methyclothiazide

中文名稱(chēng)：甲氯噻嗪

目錄號(hào)：S4057 Purity: 99.84%

Methyclothiazide是一種噻嗪類(lèi)利尿劑，可以抑制去甲腎上腺素誘導(dǎo)的收縮響應(yīng)，這是由依賴(lài)內(nèi)皮細(xì)胞的機(jī)制介導(dǎo)的，包括血管內(nèi)皮依賴(lài)性舒張因子(EDRF)和一氧化氮 (NO) 的釋放。

Methyclothiazide Chemical Structure

CAS: 135-07-9

規(guī)格	價(jià)格	庫(kù)存
50mg	794.52	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次： S405701 DMSO]72 mg/mL]false]Ethanol]4 mg/mL]false]Water]Insoluble]false 純度： 99.84%

99.84

Methyclothiazide相關(guān)產(chǎn)品

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相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 多樣性化合物母核庫(kù)	點(diǎn)擊展開(kāi)

生物活性

產(chǎn)品描述	Methyclothiazide是一種噻嗪類(lèi)利尿劑，可以抑制去甲腎上腺素誘導(dǎo)的收縮響應(yīng)，這是由依賴(lài)內(nèi)皮細(xì)胞的機(jī)制介導(dǎo)的，包括血管內(nèi)皮依賴(lài)性舒張因子(EDRF)和一氧化氮 (NO) 的釋放。
特性	一種利尿的抗高血壓藥，是苯并噻二嗪(噻嗪)類(lèi)藥物的一種。

體外研究(In Vitro)
體外研究活性	Methyclothiazide (0.1 mM)減少Ca²⁺攣縮，在SHR主動(dòng)脈環(huán)內(nèi)皮中的最大抑制為90.4%。在SHR主動(dòng)脈環(huán)功能性?xún)?nèi)皮中，Methyclothiazide (0.1 mM)對(duì)Ca²⁺攣縮的抑制作用顯著，但會(huì)被NO合酶抑制劑完全廢止。 Methyclothiazide (0.1 mM)內(nèi)膜依賴(lài)性抑制自發(fā)性高血壓大鼠(SHR)主動(dòng)脈對(duì)NE和AVP的血管收縮響應(yīng)，相對(duì)于血壓正常的Wistar Kyoto大鼠(WKY)，NE和AVP的最大血管收縮作用分別下降59%和32.3%。 Methyclothiazide (3.5 mM)抑制大鼠腎切片中腎素的釋放。

體內(nèi)研究(In Vivo)
體內(nèi)研究活性	Methyclothiazide (最初5周為0.1克/升，接下來(lái)的2周為0.2克/升，飲用水)減弱鹽敏感(DS)大鼠高血壓的發(fā)展，但是不影響耐鹽(DR)大鼠的血壓。在第3周和4周時(shí)，Methyclothiazide處理的DOCA-鹽大鼠比對(duì)照組或無(wú)增補(bǔ)的DOCA-鹽大鼠體重低。Methyclothiazide加入到DOCA-鹽大鼠的飲用水中，減弱血壓升高。

參考文獻(xiàn)
[1]https://pubmed.ncbi.nlm.nih.gov/11070184/ [2]https://pubmed.ncbi.nlm.nih.gov/11030443/ [3]https://pubmed.ncbi.nlm.nih.gov/760897/ [4]https://pubmed.ncbi.nlm.nih.gov/6191135/ [5]https://pubmed.ncbi.nlm.nih.gov/6502916/ + 展開(kāi)

參考文獻(xiàn)

[1]https://pubmed.ncbi.nlm.nih.gov/11070184/
[2]https://pubmed.ncbi.nlm.nih.gov/11030443/
[3]https://pubmed.ncbi.nlm.nih.gov/760897/

[4]https://pubmed.ncbi.nlm.nih.gov/6191135/
[5]https://pubmed.ncbi.nlm.nih.gov/6502916/

+ 展開(kāi)

化學(xué)信息&溶解度

分子量	360.24	分子式	C₉H₁₁Cl₂N₃O₄S₂
CAS號(hào)	135-07-9	SDF	--
Smiles	CN1C(NC2=CC(=C(C=C2S1(=O)=O)S(=O)(=O)N)Cl)CCl
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 72 mg/mL ( (199.86 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Ethanol : 4 mg/mL (11.1 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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