Kaempferol

別名: NSC 407289, Robigenin 中文名稱：山奈酚

目錄號(hào)：S2314 Purity: 99.86%

Kaempferol是一種黃酮，是ERRα和ERRγ的反向激動(dòng)劑。抑制topoisomerase I催化的DNA再連接和fatty acid synthase的活性。

Kaempferol Chemical Structure

CAS: 520-18-3

規(guī)格	價(jià)格	庫存
50mg	647.01	現(xiàn)貨
200mg	1056.51	現(xiàn)貨
更大包裝有超大折扣
400-668-6834 info@selleck.cn

產(chǎn)品質(zhì)控

批次：純度： 99.86%

99.86

Kaempferol相關(guān)產(chǎn)品

相關(guān)靶點(diǎn)	Estrogen receptor Progesterone receptor ERR	點(diǎn)擊展開
相關(guān)產(chǎn)品	Cholesterol PHTPP G15 Licochalcone A Endoxifen HCl Pregnenolone Chrysin AZD9496 Lasofoxifene Tartrate G-1 (LNS 8801) Hexestrol H3B-5942 Liquiritigenin Bavachin Brilanestrant (GDC-0810) Camizestrant (AZD9833) Genistin (Genistoside) MPP dihydrochloride Erteberel (LY500307) Equol Gestodene ERR alpha Rabbit Recombinant mAb DY131 Elacestrant (RAD1901) Dihydrochloride GSK5182 Enclomiphene Citrate Propyl pyrazole triol (PPT)	點(diǎn)擊展開
相關(guān)化合物庫	FDA藥物庫天然產(chǎn)物庫已知活性藥物庫-I 外泌體分泌相關(guān)化合物庫人類激素相關(guān)化合物庫	點(diǎn)擊展開

細(xì)胞實(shí)驗(yàn)數(shù)據(jù)示例

細(xì)胞系	實(shí)驗(yàn)類型	給藥濃度	孵育時(shí)間	活性描述
human U87 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human U87 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human A549 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human A549 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human MCF7 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
MDA-MB-231 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human NCI-H2126 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human NCI-H2126 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human SMMC7721 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human PANC1 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
human BxPC3 cells	Cytotoxicity assay	5-40 μM	72 h	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability at 5 to 40 uM after 72 hrs by MTT assay
MDCK cells	Function assay	50 μM		Antiviral activity against influenza A virus H1N1 A/PR/8/34 infected in MDCK cells assessed as reduction in fluorescence positive cells at 50 uM immunofluorescence assay
human MV4-11 cells	Cytotoxicity assay		72 h	Cytotoxicity against human MV4-11 cells harboring FLT3 mutation after 72 hrs by tetrazolium based Ez CyTox cell viability assay, GI50=3.34 μM
HEK293 FS cells	Function assay			Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=1.2 μM
human HeLa cells	Function assay			Inhibition of MRP1 transfected in human HeLa cells assessed as inhibition of [3H]LTC4 transport by rapid filtration assay, Ki=2.4 μM
MDCK cells	Function assay			Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining, IC50=4.7 μM
human MDA-kb2 cells	Function assay			Antagonist activity at androgen receptor in human MDA-kb2 cells assessed as inhibition of DHT-induced luciferase activity by luciferase reporter gene assay, IC50=9.7 μM
B16-4A5 cells	Function assay			Inhibition of melanogenesis in theophylline-stimulated mouse B16-4A5 cells after 72 hrs, IC50=20 μM
human HL60 cells	Cytotoxicity assay			Cytotoxicity against human HL60 cells assessed as cell survival at 50 uM after 72 hrs by CCK8 assay
mouse 3T3L1 cells	Function assay			Inhibition of AMPK-mediated adipocyte differentiation in mouse 3T3L1 cells
mouse RAW264.7 cells	Function assay			Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as nitrite level at 1 to 100 uM after 24 hrs by Griess method
mouse L929 cells	Function assay			Inhibition of recombinant human TNF-alpha-induced cytotoxicity of mouse L929 cells assessed as survivality treated with drug after 2 hrs of TNFalpha treatment
點(diǎn)擊查看更多細(xì)胞系數(shù)據(jù)

生物活性

產(chǎn)品描述

Kaempferol是一種黃酮，是ERRα和ERRγ的反向激動(dòng)劑。抑制topoisomerase I催化的DNA再連接和fatty acid synthase的活性。

靶點(diǎn)

ERRα

ERRγ

Topo I

fatty acid synthase

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT05073523	Completed	Healthy	Chalmers University of Technology	September 27 2021	Not Applicable

參考文獻(xiàn)
[1]https://pubmed.ncbi.nlm.nih.gov/19171140/ [2]http://www.jbc.org/content/271/4/2262.full [3]https://www.ncbi.nlm.nih.gov/pubmed/?term=14567550

參考文獻(xiàn)

[1]https://pubmed.ncbi.nlm.nih.gov/19171140/
[2]http://www.jbc.org/content/271/4/2262.full
[3]https://www.ncbi.nlm.nih.gov/pubmed/?term=14567550

化學(xué)信息&溶解度

分子量	286.23	分子式	C₁₅H₁₀O₆
CAS號(hào)	520-18-3	SDF	Download Kaempferol SDF
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 57 mg/mL ( (199.14 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請使用新開封DMSO)

Ethanol : 3 mg/mL (10.48 mM)

Water : Insoluble

DMSO : 57 mg/mL ( (199.14 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請使用新開封DMSO)

Ethanol : 14 mg/mL (48.91 mM)

Water : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

技術(shù)支持

在訂購、運(yùn)輸、儲(chǔ)存和使用我們的產(chǎn)品的任何階段，您遇到的任何問題，均可以通過撥打我們的熱線電話400-668-6834，或者技術(shù)支持郵箱tech@selleck.cn，直接聯(lián)系到我們。我們會(huì)在24小時(shí)內(nèi)盡快聯(lián)系您。

操作手冊

如果有其他問題，請給我們留言。

* 必填項(xiàng)

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线