Nicotinuric acid

別名: NUA 中文名稱：酰基甘氨酸, 煙酰甘氨酸, 煙尿酸

目錄號(hào)：S3322 Purity: 99.05%

Nicotinuric acid (NUA) 是煙酸的主要排毒產(chǎn)物，可以作為煙酸在肝臟生物轉(zhuǎn)化中的簡(jiǎn)單定量指標(biāo)。

Nicotinuric acid Chemical Structure

CAS: 583-08-4

規(guī)格	價(jià)格	庫(kù)存
25mg	810.81	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次： S332201 DMSO]36 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false 純度： 99.05%

99.05

Nicotinuric acid相關(guān)產(chǎn)品

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相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 多樣性化合物母核庫(kù)	點(diǎn)擊展開

生物活性

產(chǎn)品描述	Nicotinuric acid (NUA) 是煙酸的主要排毒產(chǎn)物，可以作為煙酸在肝臟生物轉(zhuǎn)化中的簡(jiǎn)單定量指標(biāo)。

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT03462680	Completed	Parkinson''s Disease	VA Office of Research and Development	September 28 2016	Not Applicable
NCT01583647	Terminated	Hypercholesterolemia Familial\|Heterozygous Familial Hypercholesterolemia	Merck Sharp & Dohme LLC	June 2012	Phase 1

參考文獻(xiàn)
[1]https://pubmed.ncbi.nlm.nih.gov/3243933/

參考文獻(xiàn)

[1]https://pubmed.ncbi.nlm.nih.gov/3243933/

化學(xué)信息&溶解度

分子量	180.16	分子式	C₈H₈N₂O₃
CAS號(hào)	583-08-4	SDF	--
Smiles	OC(=O)CNC(=O)C1=CC=CN=C1
儲(chǔ)存條件(自收到貨起)	3年 -20°C 粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年 -20°C 粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 36 mg/mL ( (199.82 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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