Bisacodyl

中文名稱：比沙可啶

目錄號(hào)：S4047 Purity: 99.9%

Bisacodyl 是一種刺激性瀉藥，直接作用于結(jié)腸產(chǎn)生排便效應(yīng)。

Bisacodyl Chemical Structure

CAS: 603-50-9

規(guī)格	價(jià)格	庫(kù)存
10mM (1mL in DMSO)	1067.09	現(xiàn)貨
50mg	794.41	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次： S404701 DMSO]72 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false 純度： 99.9%

99.9

Bisacodyl相關(guān)產(chǎn)品

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相關(guān)化合物庫(kù)	FDA藥物庫(kù) 天然產(chǎn)物庫(kù) 已知活性藥物庫(kù)-I 多樣性化合物母核庫(kù)	點(diǎn)擊展開(kāi)

生物活性

產(chǎn)品描述	Bisacodyl 是一種刺激性瀉藥，直接作用于結(jié)腸產(chǎn)生排便效應(yīng)。

體外研究(In Vitro)
體外研究活性	Bisacodyl (10微克/毫升)增加Raw264.7細(xì)胞中TNF-α，COX2和PGE2的mRNA表達(dá)水平。

體內(nèi)研究(In Vivo)
體內(nèi)研究活性	在大鼠結(jié)腸中，Bisacodyl (20 毫克/千克)導(dǎo)致AQP3蛋白質(zhì)表達(dá)減少，而TNF-α的mRNA表達(dá)水平增加。 Bisacodyl抑制大鼠空腸，回腸，和結(jié)腸的吸水率，在0.05毫克到2.0毫克每100毫升的范圍內(nèi)，抑制程度與bisacodyl濃度的對(duì)數(shù)線性相關(guān)。 Bisacodyl (10 毫克/千克，灌胃)引起大鼠空腸NOS活性顯著下降。Bisacodyl (10 毫克/千克，灌胃)增加所有時(shí)間段標(biāo)記的行進(jìn)距離。與生理鹽水處理的大鼠相比，Bisacodyl (5.9 毫克/千克)顯著降低大鼠空腸和結(jié)腸(Na + K) ATPase活性。與不影響cAMP含量的對(duì)照組大鼠相比，Bisacodyl (5.9 毫克/千克)顯著增加空腸和結(jié)腸中PGE2含量，并刺激空腸和結(jié)腸腺苷酸環(huán)化酶的活性。 Bisacodyl (4.3 毫克/千克)與AOM一起增加大鼠體內(nèi)每個(gè)集落小囊的數(shù)量，但是不增加腫瘤的數(shù)量。Bisacodyl (4.3 毫克/千克)顯著增加大鼠每個(gè)集落小囊和腫瘤的數(shù)量。

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗(yàn)信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT06219707	Not yet recruiting	Irritable Bowel Syndrome With Constipation	Nanyang Technological University\|National University of Singapore	March 1 2024	Not Applicable
NCT05770960	Completed	Opioid-Induced Constipation	Universitaire Ziekenhuizen KU Leuven	June 27 2018	Phase 4
NCT03279341	Completed	Chronic Constipation	University Hospital Gasthuisberg	December 3 2012	Phase 4
NCT01424228	Completed	Constipation	Shire\|Takeda	April 6 2011	Phase 4

參考文獻(xiàn)
[1]https://pubmed.ncbi.nlm.nih.gov/21868635/ [2]https://pubmed.ncbi.nlm.nih.gov/849815/ [3]https://pubmed.ncbi.nlm.nih.gov/9282971/ [4]https://pubmed.ncbi.nlm.nih.gov/6249558/ [5]https://pubmed.ncbi.nlm.nih.gov/11693267/ + 展開(kāi)

參考文獻(xiàn)

[1]https://pubmed.ncbi.nlm.nih.gov/21868635/
[2]https://pubmed.ncbi.nlm.nih.gov/849815/
[3]https://pubmed.ncbi.nlm.nih.gov/9282971/

[4]https://pubmed.ncbi.nlm.nih.gov/6249558/
[5]https://pubmed.ncbi.nlm.nih.gov/11693267/

+ 展開(kāi)

化學(xué)信息&溶解度

分子量	361.39	分子式	C₂₂H₁₉NO₄
CAS號(hào)	603-50-9	SDF	Download Bisacodyl SDF
Smiles	CC(=O)OC1=CC=C(C=C1)C(C2=CC=C(C=C2)OC(=O)C)C3=CC=CC=N3
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲(chǔ)存條件(自收到貨起)	3年-20°C粉狀	儲(chǔ)備液保存和期限建議分裝儲(chǔ)備液，避免反復(fù)凍融！	1個(gè)月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 72 mg/mL ( (199.23 mM) ；DMSO吸濕會(huì)降低化合物溶解度，請(qǐng)使用新開(kāi)封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計(jì)算器

體內(nèi)溶解配方
批次：

現(xiàn)配現(xiàn)用，請(qǐng)按從左到右的順序依次添加，澄清后再加入下一溶劑

動(dòng)物體內(nèi)配方計(jì)算器

實(shí)驗(yàn)計(jì)算

摩爾濃度計(jì)算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計(jì)算器分子量計(jì)算器

動(dòng)物體內(nèi)配方計(jì)算器（澄清溶液）

第一步：請(qǐng)輸入基本實(shí)驗(yàn)信息（考慮到實(shí)驗(yàn)過(guò)程中的損耗，建議多配一只動(dòng)物的藥量）

給藥劑量 mg/kg 動(dòng)物平均體重 g 每只動(dòng)物給藥體積 μL 動(dòng)物數(shù)量只

第二步：請(qǐng)輸入動(dòng)物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請(qǐng)聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計(jì)算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過(guò)該批次藥物DMSO溶解度，請(qǐng)先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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