PNC-27 is a synthetically created peptide designed to specificsally target and destroy cancer cells. It is a member of the PNC set of investigational proteins designed to attach to malformed(cancerous) cells and cause them to die through cell necrosis, all while leaving normal, healthy cells intact and unharmed.

The PNC-27 peptide contains an HDM-2 binding domain colrresponding to residues 12-26 of p53 and a transmembrane-

penetrating domain. This has been found to enable the peptide to bind to and kill cancer cells through membranolysis, or disruption of the cell membrane.

Through research and study on animal subjects, the PNC-27 peptide has been shown to be highly effective in selectively targeting a wide variety of specific forms of cancer, including pancreatic caancer, breast cancer, leukemia, melanoma, and additional cancer lines.