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[CAS NO. 5072-26-4]??DL-Buthionine-(S,R)-sulfoximine

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PRODUCTS SPECIFICATIONS [5072-26-4]

Catalog
HY-106376
Brand
MCE
CAS
5072-26-4

DESCRIPTION [5072-26-4]

Overview

MDLMFCD00070309
Molecular Weight222.31
Molecular FormulaC8H18N2O3S
SMILESOC(C(N)CCS(CCCC)(=N)=O)=O

For research use only. We do not sell to patients.


Summary

DL-Buthionine-(S,R)-sulfoximine is a potent inhibitor of glutamylcysteine synthetase biosynthesis .


IC50 & Target

glutamylcysteine synthetase [1]


In Vitro

Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


In Vivo

Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors [2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Clinical Trial

NCT Number Sponsor Condition Start Date Phase
NCT00002730 Children′s Hospital Los Angeles|National Cancer Institute (NCI)
Neuroblastoma
June 1996 Phase 1
NCT00661336 Duke University|National Cancer Institute (NCI)
Melanoma (Skin)
April 2008 Phase 1
NCT00005835 New Approaches to Neuroblastoma Therapy Consortium|National Cancer Institute (NCI)
Neuroblastoma
August 2001 Phase 1

Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

H 2 O : 25 mg/mL ( 112.46 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4982 mL 22.4911 mL 44.9822 mL
5 mM 0.8996 mL 4.4982 mL 8.9964 mL
10 mM 0.4498 mL 2.2491 mL 4.4982 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: PBS

    Solubility: 100 mg/mL (449.82 mM); Clear solution; Need ultrasonic

* All of the co-solvents are available by MCE.


Synonyms

Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Sulfoximine, S-(3-amino-3-carboxypropyl)-S-butyl-
Sulfoximine, 3-amino-3-carboxypropyl butyl
2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Butionine sulfoximine
Buthionine sulfoximine
DL-Buthionine (S,R)-sulfoximine
NSC 381100

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