公司官網(wǎng) http://www.staherb.com/ 資質(zhì):HALAL, KOSHER等認(rèn)證

?：19573130018 楊經(jīng)理（微信同號(hào)）

中文主要活性成分簡(jiǎn)介｜Key Active Constituents (CN)

產(chǎn)品：姜黃提取物 Turmeric Extract / 姜黃素 Curcuminoids（姜科 Zingiberaceae 姜黃 Curcuma longa L. 干燥根莖）

供應(yīng)商：長(zhǎng)沙上禾生物科技有限公司（Changsha Staherb Natural Ingredients Co., Ltd. / Staherb?）

整體提取物無(wú)單一 CAS，以 姜黃素 Curcumin CAS 458-37-7 作首要 HPLC Marker、以 總姜黃素 Curcuminoids（Curcumin+DMC+BDMC 之和） 作標(biāo)化總量標(biāo)識(shí)；揮發(fā)油段以 姜黃酮 Turmerone / 芳姜黃酮 ar-Turmerone 作 GC-MS 伴行 Marker。

規(guī)格—活性對(duì)應(yīng)（Staherb 標(biāo)化）：

• 總姜黃素（HPLC，三者之和）：5% / 10% / 30% / 50% / 65% / 95%（95% 批按 USP 比例：Curcumin 70%–80%、DMC 15%–25%、BDMC 2.5%–6.5%）；

• 高純單體：Curcumin ≥95% / 98% HPLC-UV@425 nm（橙黃至紅棕結(jié)晶粉）；

• 全譜/比例粉：10:1 / 20:1 / 30:1，揮發(fā)油 ≥2%–10% GC、姜黃酮/芳姜黃酮定性定量選報(bào)；

• 改型：水溶性姜黃素（10%–20% HPLC，β-CD/磷脂/納米乳）、四氫姜黃素（Tetrahydrocurcumin 36062-04-1 選供）。

姜黃不是"單分子植物"，而是"二芳基庚烷類姜黃素三聯(lián)體（主軸）+ 姜黃酮倍半萜揮發(fā)油 + 少量多糖/甾醇"嵌合矩陣，主要活性成分分述如下：

1. 姜黃素 Curcumin（絕對(duì)主軸與 HPLC Marker）

• 1,7-雙(4-羥基-3-甲氧基苯基)-1,6-庚二烯-3,5-二酮（二feruloyl methane），C??H??O? / MW 368.38，CAS 458-37-7，橙黃至紅棕結(jié)晶；酮-烯醇互變異構(gòu)（酸/中性酮式為主、堿性烯醇式紅褐），pH 1–6 穩(wěn)、不溶于水、溶于乙醇/丙酮/DMSO/油脂；占干姜黃 2%–5% DW、占姜黃素類 70%–77%。

• 是 NF-κB/MAPK/Nrf2/PI3K-Akt 多靶點(diǎn)抑制的經(jīng)典多酚，也是食品級(jí)黃色素（E100 背景）。

2. 去甲氧基姜黃素 Demethoxycurcumin（DMC，伴行第二峰）

• 4-羥基-3-甲氧基與 4-羥基對(duì)稱去一個(gè) OMe，C??H??O? / MW 338.35，CAS 22608-11-3；占姜黃素類 15%–25%（USP 95% 批下限）。

• 部分研究示其 NLRP3/腸屏障/生物利用度略優(yōu)于 Curcumin 本體（DMC 在 DSS 結(jié)腸炎模型抗炎伴行更強(qiáng)背景）。

3. 雙去甲氧基姜黃素 Bisdemethoxycurcumin（BDMC，伴行第三峰）

• 兩端均去 OMe 的對(duì)稱二羥基二苯基庚二烯二酮，C??H??O? / MW 308.33，CAS 24939-16-8（文獻(xiàn)亦見 33171-05-0 同物異錄）；占姜黃素類 2.5%–6.5%（USP 95% 批下限）。

• 抗氧化/金屬螯合背景，體外活性常介于 Curcumin 與 DMC 之間。

4. 揮發(fā)油段——姜黃酮類（Turmerones，伴行調(diào)性分子）

• 姜黃酮 Turmerone（C??H??O/MW218）、芳姜黃酮 ar-Turmerone（C??H??O/MW218）、姜烯 Zingiberene 等倍半萜；占根莖揮發(fā)油主體，賦予姜黃特有芳香與部分抗炎/促膽汁/神經(jīng)背景，但不算"姜黃素類"總量。

• Staherb 全譜批隨 GC-MS 報(bào)"Volatile oil ≥2%–10%，Turmerone/ar-Turmerone 定性定量"。

5. 伴生微量

• 四氫姜黃素 Tetrahydrocurcumin（36062-04-1，體內(nèi)還原代謝物，更水溶）、二氫姜黃素、環(huán)姜黃素、姜黃多糖、豆甾醇/β-谷甾醇——與姜黃素類協(xié)同"抗炎-抗氧化"背景。

為什么它是"主要活性成分"表述難點(diǎn)

姜黃功效不是單分子負(fù)責(zé)——Curcumin 是首要 Marker 與多酚主軸，DMC/BDMC 伴行協(xié)同（三者之和才叫"總姜黃素"），Turmerone 管芳香與部分膽道/神經(jīng)背景，多糖/甾醇補(bǔ)位。Staherb 原料頁(yè)表述為"Curcumin as primary diarylheptanoid marker + DMC/BDMC as companion curcuminoids (sum = total curcuminoids) + turmerones as volatile companion"，并強(qiáng)制標(biāo)注"總姜黃素 HPLC 必含三峰比例，不可只報(bào) Curcumin 冒充 95% 姜黃素類"；單體 Curcumin≥98% 另線。

Staherb 產(chǎn)品中的活性表達(dá)形態(tài)

• 標(biāo)化提取物：總姜黃素 5%–95% HPLC（95% 批三峰合 USP）、10:1–30:1 全譜粉（伴揮發(fā)油）；

• 高純單體：Curcumin≥95%/98% HPLC-UV@425 nm 橙晶；

• 改型：水溶性姜黃素 10%–20%、磷脂復(fù)合（吸收 5–10×）、納米姜黃素（生物利用度 20–30× 背景）、四氫姜黃素選供。

?? Staherb 合規(guī)邊界：原料頁(yè)統(tǒng)一表述"diarylheptanoid curcuminoid matrix (Curcumin-led + DMC + BDMC) + turmerone volatile companion active for anti-inflammatory-background / antioxidant / metabolic-background / neuro-background / natural colorant / pharma R&D reference"；Curcumin 口服生物利用度極低（<1%–5%）、水溶差、堿性變紅褐、Fe3?/Cu2? 變色，不作"治療類風(fēng)濕關(guān)節(jié)炎/腫瘤/阿爾茨海默/脂肪肝"主治宣稱；所有出口批附 "food/dietary-ingredient & R&D intermediate, not self-medication；充氮鋁箔避光 2–8℃ 防潮（單體 -20℃）；配方避強(qiáng)堿（pH>7 變紅褐）、避 Fe/Cu 離子、需磷脂/β-CD/胡椒堿/納米乳增溶；抗凝藥/膽石癥/術(shù)前 1–2 周聯(lián)用問醫(yī)；長(zhǎng)期高劑量 >3–8 g 原生姜黃粉/日 遵當(dāng)?shù)厣舷? 警示。

English Key Active Constituents｜EN

Product: Turmeric Extract / Curcuminoids (Rhizome of Curcuma longa L., Zingiberaceae)

Supplier: Changsha Staherb Natural Ingredients Co., Ltd. (Staherb?)

Whole extract no single CAS, flagged by Curcumin CAS 458-37-7 as primary HPLC marker, Total Curcuminoids (Curcumin + DMC + BDMC sum) as standardized total, Turmerone / ar-Turmerone as GC-MS volatile companion.

Spec?active map (Staherb):

• Total Curcuminoids (HPLC 3-peak sum): 5%/10%/30%/50%/65%/95% (95% batch per USP: Curcumin 70%–80%, DMC 15%–25%, BDMC 2.5%–6.5%);

• High-pure monomer: Curcumin ≥95%/98% HPLC-UV@425 nm (orange-reddish-brown crystal);

• Full-spectrum/ratio: 10:1/20:1/30:1, volatile oil ≥2%–10% GC, turmerone/ar-turmerone optional quant;

• Modified: water-soluble curcumin 10%–20% (β-CD/phospholipid/nano-emulsion), tetrahydrocurcumin (36062-04-1) optional.

Turmeric is not a single-molecule herb but a "diarylheptanoid curcuminoid triplet (spine) + turmerone sesquiterpene volatile oil + minor polysaccharide/sterol" embed; key actives:

1. Curcumin — absolute spine & HPLC marker

• 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (diferuloylmethane), C??H??O? / MW 368.38, CAS 458-37-7, orange-reddish-brown crystal; keto-enol tautomer (keto dominant acid/neutral, enol red-brown alkaline), stable pH 1–6, water-insoluble, soluble EtOH/acetone/DMSO/oils; 2%–5% DW of dry rhizome, 70%–77% of curcuminoid fraction.

• Classic polyphenol inhibiting NF-κB/MAPK/Nrf2/PI3K-Akt multi-target; also food yellow color (E100 background).

2. Demethoxycurcumin (DMC) — companion 2nd peak

• One OMe removed symmetrically, C??H??O? / MW 338.35, CAS 22608-11-3; 15%–25% of curcuminoids (USP 95% floor).

• Some studies show NLRP3/gut-barrier/bioavailability slightly superior to Curcumin itself (DMC stronger companion in DSS-colitis background).

3. Bisdemethoxycurcumin (BDMC) — companion 3rd peak

• Both OMe removed symmetric dihydroxy-diarylheptadienedione, C??H??O? / MW 308.33, CAS 24939-16-8 (also recorded 33171-05-0); 2.5%–6.5% of curcuminoids (USP 95% floor).

• Antioxidant/metal-chelating background, in-vitro activity between Curcumin and DMC.

4. Volatile oil — turmerones (companion tone molecules)

• Turmerone (C??H??O/MW218), ar-Turmerone (C??H??O/MW218), zingiberene sesquiterpenes; main of rhizome volatile oil, give characteristic aroma + partial anti-inflammatory/cholagogue/neuro background, NOT counted in "curcuminoids total**.

• Staherb full-spectrum batch reports "Volatile oil ≥2%–10% GC, turmerone/ar-turmerone qual/quant".

5. Minor companions

• Tetrahydrocurcumin (36062-04-1, in-vivo reduced metabolite, more water-soluble), dihydrocurcumin, cyclo-curcumin, turmeric polysaccharide, stigmasterol/β-sitosterol — synergy with curcuminoids "anti-inflammatory-antioxidant" background.

Why "key active" is a matrix statement

Turmeric efficacy not one molecule — Curcumin is primary marker & polyphenol spine, DMC/BDMC companion-synergize (their sum = total curcuminoids), turmerones run aroma & partial biliary/neuro background, polysac/sterol fill. Staherb labels "Curcumin as primary diarylheptanoid marker + DMC/BDMC as companion curcuminoids (sum = total curcuminoids) + turmerones as volatile companion" and mandates "total curcuminoids HPLC must report 3-peak ratio, cannot report only Curcumin to fake 95% curcuminoids"; Curcumin≥98% monomer separate line.

Active form in Staherb portfolio

• Std extract: total curcuminoids 5%–95% HPLC (95% USP 3-peak), 10:1–30:1 full-spectrum (with volatile oil);

• High-pure: Curcumin≥95%/98% HPLC-UV@425 nm orange crystal;

• Modified: water-soluble 10%–20%, phospholipid complex (5–10× uptake), nano-curcumin (20–30× bioavailability background), tetrahydrocurcumin optional.

Supplier note: Staherb labels Turmeric Extract as "diarylheptanoid curcuminoid matrix (Curcumin-led + DMC + BDMC) + turmerone volatile companion active for anti-inflammatory-background / antioxidant / metabolic-background / neuro-background / natural colorant / pharma R&D reference" — Curcumin oral bioavailability very low (<1%–5%), water-poor, alkaline red-brown, Fe3?/Cu2? discolor, no "treats RA/tumor/Alzheimer/NAFLD" indication; every export lot carries "food/dietary-ingredient & R&D intermediate, not self-medication; N? foil dark 2–8℃ dry (monomer -20℃); formula avoid strong alkali (pH>7 red-brown), avoid Fe/Cu ions, need phospholipid/β-CD/piperine/nano-emulsion solubilize; anticoagulant/gallstone/pre-1–2wk-surgery consult physician; long-term >3–8 g raw turmeric/day follow local cap" warning.

公司官網(wǎng) http://www.staherb.com/ 資質(zhì):HALAL, KOSHER等認(rèn)證

?：19573130018 楊經(jīng)理（微信同號(hào)）