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主營產(chǎn)品:細(xì)胞,轉(zhuǎn)染細(xì)胞,標(biāo)記細(xì)胞,PCR試劑盒

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文獻(xiàn)引用產(chǎn)品:豬腫瘤壞死因子α(TNF-α)Elisa試劑盒

發(fā)布日期:2026/6/18 9:20:42發(fā)布人:上海雅吉生物科技有限公司閱讀量:13

?文章標(biāo)題:Lysozyme improves gut performance and protects against enterotoxigenic Escherichia coli infection in neonatal piglets

作者列表:Huang Guangping, Li Xiangqing, Lu Dan, Liu Shen, Suo Xun, Li Qiuyan, Li Ning
影響因子:2.903
期刊:VETERINARY RESEARCH
發(fā)表時(shí)間:2018-2-20
DOI:10.1186/s13567-018-0511-4
文獻(xiàn)主題:Abstract
Diarrhea remains one of the leading causes of morbidity and mortality globally, with enterotoxigenic Escherichia coli (ETEC) constituting a major causative pathogen. The development of alternative treatments for diarrhea that do not involve chemotherapeutic drugs or result in antibiotic resistance is critical. Considering that lysozyme is a naturally occurring antimicrobial peptide, in a previous study we developed a transgenic pig line that expresses recombinant human lysozyme (hLZ) in its milk. In the present study, we examined the protective effects of the consumption of this milk against ETEC infection in neonatal piglets. We found that consuming hLZ milk facilitated faster recovery from infection and decreased mortality and morbidity following an ETEC oral inoculation or infection acquired by contact-exposure. The protective effect of hLZ was associated with the enrichment of intestinal bacteria that improve gut health, such as Lactobacillus, and the enhancement of the mucosal IgA response to the ETEC-induced diarrhea. Our study revealed potential protective mechanisms underlying the antimicrobial activity of human lysozyme, validating the use of lysozyme as an effective preventive measure for diarrhea.



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