公司官網(wǎng) http://www.staherb.com/ 資質(zhì):HALAL, KOSHER等認證
?：19573130018 楊經(jīng)理（微信同號）
一、中文簡介（Chinese Introduction）
活性成分名稱：槲皮素（Quercetin），別名櫟精、槲皮黃素、Meletin、Sophoretin。
化學(xué)歸屬：天然黃酮類化合物，屬黃酮醇亞類，具有典型的C6-C3-C6碳骨架（2-苯基色原酮結(jié)構(gòu)），化學(xué)名為 3,3',4',5,7-五羥基黃酮 或 2-(3,4-二羥基苯基)-3,5,7-三羥基-4H-1-苯并吡喃-4-酮。
理化標識：
CAS號：117-39-5（無水物）；6151-25-3（二水合物）
分子式：C??H??O?（無水）；C??H??O?·2H?O（二水合物）
分子量：302.24（無水）；338.27（二水合物）
性狀：黃色至黃綠色結(jié)晶性粉末，無臭，味微苦；極難溶于水，微溶于冷乙醇，可溶于熱乙醇、甲醇、乙酸乙酯、冰醋酸及堿性水溶液（顯黃色），熔點約314℃（分解）。
活性來源與轉(zhuǎn)化：槐米中原生形態(tài)主要以蘆?。≧utin，槲皮素-3-O-蕓香糖苷）存在，含量可達10%~20%；上禾生物通過堿提酸沉、生物酶解（蘆丁水解）及柱層析/重結(jié)晶工藝，脫去糖基獲得游離態(tài)槲皮素 ≥98%（HPLC）。其分子結(jié)構(gòu)中含有5個酚羥基（尤以B環(huán)鄰苯二酚結(jié)構(gòu)為關(guān)鍵），是其發(fā)揮強效抗氧化、螯合金屬離子、調(diào)節(jié)信號通路的核心結(jié)構(gòu)基礎(chǔ)。
核心活性概覽：槲皮素是植物界分布最廣的多酚之一，在槐花源高純產(chǎn)品中集中體現(xiàn)以下活性：
抗氧化與抗炎：直接清除ROS/RNS，激活Nrf2/ARE通路，抑制NF-κB、MAPK等炎癥通路；
心血管與血管保護：降低毛細血管通透性、增強抵抗力，抗動脈粥樣硬化，輔助調(diào)節(jié)血壓血脂；
抗過敏與免疫：穩(wěn)定肥大細胞膜，抑制組胺及白三烯釋放；
代謝與神經(jīng)保護：輔助降糖、調(diào)脂、抗尿酸，潛在神經(jīng)保護及細胞凋亡調(diào)節(jié)（抗腫瘤研究）。
二、English Introduction (Active Constituent Description)
Active Ingredient Name: Quercetin (Synonyms: Meletin, Sophoretin, Quercetol).
Chemical Classification: A natural flavonol belonging to the flavonoid family, characterized by the C6-C3-C6 skeleton (2-phenylchromen-4-one backbone).
Chemical Name: 3,3',4',5,7-Pentahydroxyflavone or 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one.
Physicochemical Identity:
CAS No.: 117-39-5 (anhydrous); 6151-25-3 (dihydrate)
Molecular Formula: C??H??O? (anhydrous); C??H??O?·2H?O (dihydrate)
Molecular Weight: 302.24 (anhydrous); 338.27 (dihydrate)
Properties: Yellow to yellow-green crystalline powder, odorless, slightly bitter; extremely low solubility in water, slightly soluble in cold ethanol, soluble in hot ethanol, methanol, ethyl acetate, glacial acetic acid, and alkaline aqueous solutions (yellow tint); melting point ~314℃ (dec.).
Source & Biotransformation: In Sophora japonica(Huai Mi / Flower buds), quercetin predominantly exists as its glycoside Rutin (Quercetin-3-O-rutinoside) (naturally 10%~20% dw). Staherb employs alkaline extraction-acid precipitation, enzymatic hydrolysis (rutin → quercetin + rutinose), column chromatography, and recrystallization to yield anhydrous/dihydrate Quercetin ≥98% (HPLC). Its five phenolic hydroxyl groups (notably the ortho-catechol moiety on the B-ring) constitute the core pharmacophore for potent free-radical scavenging, metal chelation (Fe2?/Cu2?), and signaling pathway modulation.
Core Bioactivities Summary: As one of the most abundant dietary polyphenols, high-purity Sophora japonica-derived Quercetin centrally manifests:
Antioxidant & Anti-inflammatory: Direct ROS/RNS neutralization, Nrf2/ARE activation, suppression of NF-κB/MAPK/NLRP3 inflammasome pathways.
Cardiovascular & Vascular Protection: Reduces capillary permeability, strengthens capillary resistance, anti-atherosclerotic potential, adjunct blood pressure/lipid modulation.
Anti-allergic & Immune: Mast cell membrane stabilization, inhibition of histamine/leukotriene release.
Metabolic & Neuroprotective: Adjunct glycemic/lipid/uric acid regulation; potential neuroprotection and apoptotic modulation (cancer chemoprevention research).
?? 特性提示：游離槲皮素水溶性極差，對光、熱（>200℃降解）、氧、堿敏感，制劑中常需納米化、環(huán)糊精包合、糖苷化（如制成蘆丁/異槲皮苷）或磷脂復(fù)合物提升生物利用度；上禾生物98%產(chǎn)品多為黃色結(jié)晶粉末，需避光、充氮、2~8℃或陰涼干燥密封保存。
公司官網(wǎng) http://www.staherb.com/ 資質(zhì):HALAL, KOSHER等認證
?：19573130018 楊經(jīng)理（微信同號）