一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

優(yōu)惠券使用說明>

暫無可領(lǐng)優(yōu)惠券

上海佰世凱生物科技有限公司

主營產(chǎn)品:醫(yī)藥中間體,藥物雜質(zhì),生物活性小分子等。

客服熱線:021-20908456

  • 手機(jī):
  • 電話:021-20908456 
  • 郵箱:sales@BioChemBest.com
  • 網(wǎng)址:http://www.BioChemBest.com
  • 地址:Building 3, No.1666, Xinyang Highway, Lin-gang Special Area of China (Shanghai) Pilot Free Trade Zone 201413 P.R. China
  • 企業(yè)認(rèn)證:
  • CB指數(shù):61
Monocrotaline(Crotaline) 野百合堿 CAS:315-22-0
發(fā)布日期:2017/3/15 13:58:06發(fā)布人:上海佰世凱化學(xué)科技有限公司閱讀量:582

CAS:315-22-0 

C11518

野百合堿

Product Name:Monocrotaline

Synonyms:野百合堿;農(nóng)吉利堿;農(nóng)吉利甲素;大葉豬屎青堿;單豬屎豆堿;可洛他林;Monocrotaline;(-)-Monocrotaline;NSC 28693

Chemical Name:2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-

Molecular Formula:C16H23NO6

Formula Weight:325.36

Purity:>99% 

Appearance:White crystalline powder 

Biological Activity:
Monocrotaline is an pyrrolizidine alkaloid extracted from the seeds of the Crotalaria spectabilis plant to induce pulmonary hypertension in rodents.

InVitro: Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid derived from the seeds of the Crotalaria spectabilis plant. Monocrotaline a natural ligand exhibits dose-dependent cytotoxicity with potent antineoplastic activity. The in vitro cytotoxicity of monocrotaline is proved at IC50 24.966 μg/mL and genotoxicity at 2 X IC50 against HepG2 cells.

InVivo: MCT causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension, and cor pulmonale. Among preclinical models of pulmonary arterial hypertension, monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection. Changes in multiple pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline.

References:
[1]. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9.
[2]. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48.
[3]. Wilson DW, et, al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992;22(5-6):307-25.
[4]. Nogueira-Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec;35:8-16.
[5]. Rafikova O,et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3;11(3):e0150480.

上海佰世凱化學(xué)科技有限公司

ChemBest Research Laboratories Ltd.

電話: 0086-21-20908456

E-mail: sales@biochembest.com


相關(guān)促銷信息

查看更多

商家暫時不對外公布

主頁 | 企業(yè)會員服務(wù) | 廣告業(yè)務(wù) | 聯(lián)系我們 | 舊版入口 | 中文MSDS | CAS Index | 常用化學(xué)品CAS列表 | 化工產(chǎn)品目錄 | 新產(chǎn)品列表 | 評選活動| HS海關(guān)編碼
Copyright © 2008 ChemicalBook 京ICP備07040585號  京公網(wǎng)安備 11010802032676號  All rights reserved.
熱線電話:010-86108875
阿瓦提县| 响水县| 崇仁县| 莎车县| 吉木乃县| 昌黎县| 昌邑市| 邵武市| 河曲县| 阿克| 大城县| 都兰县| 藁城市| 眉山市| 巩义市| 枣阳市| 安福县| 阜康市| 濉溪县| 苗栗县| 澎湖县| 柘城县| 乌鲁木齐县| 东海县| 永靖县| 米林县| 阿鲁科尔沁旗| 天气| 新郑市| 高台县| 平武县| 疏附县| 五大连池市| 萨嘎县| 应用必备| 长垣县| 南溪县| 天水市| 朝阳县| 荆州市| 麻城市|