GCLE was a new intermediate for synthetic cephalosporin antibiotics. It was the main material for synthesis of the Third and Fourth generation cephalosporin antibiotics, there are more than 60% of the varieties can be produced by GCLE. Moreover, the cephalosporin with GCLE intermediates have higher product yield, more simple production procss, more moderate production conditions, lower product cost. Especially in synthesis such as cefdinir, cefixime, ceftazidime has a very big advantage; In addition GCLE also used for the synthesis of new cephalosporins such as cefprozil which the synthesis of the traditional three nucleus can not synthesize.