PXS-5153A (PXS5153A) is a potent, selective, fast-acting, dual LOXL2/LOXL3 inhibitor with IC50 of<40 63="" nm="" against="" all="" mammalian="" species="" inhibits="" human="" loxl3="" with="" ic50="" of="" displays="">40-fold selectivity for LOXL2 over both LOX and LOXL1 and >700-fold over other related amine oxidases; dose-dependently reduced LOXL2-mediated collagen oxidation and collagen crosslinking in vitro; reduced disease severity and improved liver function by diminishing collagen content and collagen crosslinks in carbon tetrachloride or streptozotocin/high fat diet-induced liver fibrosis models.