中文名稱

拉波普蘭特; （3R）-4-[[（4-氯苯基）甲基]-7-氟-1,2,3,4-四氫-5-（甲基磺?；?環(huán)戊[b]吲哚-3-乙酸

英文名字

Laropiprant; (3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-cyclopent[b]indole-3-acetic acid

供應商

開曼生物

產品貨號

10009835-25

產品報價

￥7284.2/25mg

產品說明書

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購買方式

銀行轉賬、電匯、支票、現(xiàn)金，在線支付寶及網銀支付，或直接與我們電話聯(lián)系400-6800-868

產品新聞

背景資料

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Two seven-transmembrane G protein-coupled receptors for PGD2, designated DP1 and CRTH2/DP2, have been identified.{15538} Activation of the DP1 receptor leads to an increase of intracellular cAMP levels. However, activation of DP2 results in mobilization of intracellular Ca2+ and an apparent decrease in intracellular cAMP.{11488} MK 0524 is a potent, selective DP1 receptor antagonist with Ki values of 0.57 nM and 0.75 μM for the DP1 and DP2 receptors, respectively.{14713} It inhibits PGD2-induced accumulation of cAMP in both washed platelets and platelet-rich plasma with IC50 values of 0.09 and 4.0 nM, respectively.{14713} In a sheep model of allergic rhinitis, 0.1 mg/kg MK 0524 completely blocked PGD2-induced nasal congestion.{14713} At a dose of 4 mg/kg, MK 0524 suppressed a nicotinic acid-induced vasodilatory response by 80% in a mouse model of flushing, an undesirable side-effect of niacin treatment for dyslipidemia.{15245}

產品描述

A potent, selective DP1 receptor antagonist that binds DP1 and DP2 receptors with Ki values of 0.57 nM and 0.75 μM, respectively

保存建議

建議您在收到開曼生物品牌的MK 0524 (25 mg)產品后置于-20度保存，產品有效期為730天.

其他

開曼生物向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.開曼生物可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環(huán)核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為開曼生物在中國的區(qū)域總代理，艾美捷科技有限公司將為中國客戶提供最全面的開曼生物產品以及客戶訂制化服務.