IRDye 800CW RGD Optical Probe

IRDye 800CW RGD 光學(xué)探頭

IRDye 800CW RGD 光學(xué)探頭是一種 BrightSite? 近紅外 (NIR) 熒光標(biāo)記的 RGD 顯像劑，專門設(shè)計用于靶向上整合素的過度表達(dá)。

整聯(lián)蛋白是細(xì)胞表面異二聚體糖蛋白，參與細(xì)胞與細(xì)胞和細(xì)胞與基質(zhì)的相互作用。 IRDye 800CW RGD 光學(xué)探針由識別基序 RGD (Arg-Gly-Asp) 組成，這是一個三肽序列，用于結(jié)合包括 αvβ3 在內(nèi)的整聯(lián)蛋白受體。 

IRDye 800CW RGD Optical Probe is a BrightSite? near-infrared (NIR) fluorescently-labeled RGD imaging agent specifically designed to target the overexpression of integrins on tumors.

Integrins are cell surface heterodimeric glycoproteins involved in cell-to-cell and cell-to-matrix interactions. IRDye 800CW RGD Optical Probe is composed of the recognition motif, RGD (Arg-Gly-Asp), a tripeptide sequence used to bind integrin receptors including αvβ3. This receptor class is involved in tumor growth, tumor invasiveness, metastasis, tumor induced angiogenesis, inflammation, osteoporosis, and rheumatoid arthritis.