Name: OATD-01
CAS#: 2088453-21-6
Chemical Formula: C19H27ClN6O
Exact Mass: 390.1935
Molecular Weight: 390.92
Elemental Analysis: C, 58.38; H, 6.96; Cl, 9.07; N, 21.50; O, 4.09
Description: OATD-01, also known as GLPG 4716, is a potent and selective chitinase inhibitor for treatment of interstitial lung diseases. OATD-01 showed (hAMCase IC50=9nM, hCHIT1 IC50=26nM) significantly reduced lung fibrosis in the bleomycin-induced fibrosis model, comparably to nintedanib, as assessed by modified Ashcroft scoring. The anti-fibrotic activity of OATD-01 was associated with pharmacodynamic effect: plasma chitinolytic activity was significantly reduced in mice dosed with OATD-01 as compared to control group.
IUPAC/Chemical Name: 5-[4-[(2S,5S)-5-[(4-Chlorophenyl)methyl]-2-methyl-4-morpholinyl]-1-piperidinyl]-1H-1,2,4-triazol-3-amine
InChi Key: STWVLEKJQQRGMO-GUYCJALGSA-N
InChi Code: InChI=1S/C19H27ClN6O/c1-13-11-26(17(12-27-13)10-14-2-4-15(20)5-3-14)16-6-8-25(9-7-16)19-22-18(21)23-24-19/h2-5,13,16-17H,6-12H2,1H3,(H3,21,22,23,24)/t13-,17-/m0/s1
SMILES Code: C[C@H]1CN(C2CCN(C3=NN=C(N)N3)CC2)[C@@H](CC4=CC=C(Cl)C=C4)CO1
Appearance: Solid powder
關(guān)鍵字： 2088453-21-6;OATD-01;
北京百奧創(chuàng)新科技有限公司是一家專注于生命科學(xué)的科技企業(yè)，由在國內(nèi)科研試劑領(lǐng)域有著豐富從業(yè)經(jīng)驗的技術(shù)團(tuán)隊和管理團(tuán)隊組建而成，專營進(jìn)口生物試劑，科學(xué)儀器，實(shí)驗消耗品等。公司與諸多國外品牌簽下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能為廣大科研用戶提供數(shù)萬種試劑、儀器和實(shí)驗消耗品。
公司將不斷把上優(yōu)質(zhì)的產(chǎn)品引入國內(nèi)市場，滿足客戶的需求，公司也將緊跟生命科學(xué)的發(fā)展，為廣大科研工作者探索生命科學(xué)的奧秘奉獻(xiàn)綿薄之力！