中文名稱

D，L-C16-二氫鞘氨醇（混合異構體）

英文名字

D,L-C16-Dihydrosphingosine (mixed isomers)

供應商

Matreya

產品貨號

1326-10

背景資料

This dihydrosphingosine standard is a mixture of D and L isomers and contains approximately 90% erythro and 10% threo isomers. It is a 16 carbon chain, two carbons shorter than the most prevalent dihydrosphingosine in most animals. However, some animals, such as Drosophila melanogaster, have the shorter C16 dihydrosphingosine base.1 Dihydrosphingosine (Sphinganine) is the precursor of dihydroceramide which is then desaturated to form ceramide. It is a critical intermediate in the synthesis of many complex sphingoid bases and ceramide analogs. It has been found that sphinganine can induce cell death in a number of types of malignant cells and is being tested for its pharmacological properties.2 Inhibition of dihydroceramide synthesis by some fungal toxins that have a similar structure causes an increase in sphinganine and sphinganine-1-phosphate and a decrease in other sphingolipids leading to a number of diseases including oesophageal cancer.3 Sphinganine has been found to mediate fumonisin (a toxic sphinganine analog) induced hypotension.4

產品描述

D,L-Sphinganine,C16 chain

產品形式

該D，L-C16-二氫鞘氨醇（混合異構體）產品為固體形式

保存建議

對于本產品，我們推薦使用-20℃藍冰低溫進行運輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請參考本品說明書。