中文名稱(chēng)

A-FABP抑制劑| ALBP抑制劑|脂肪細(xì)胞FABP抑制劑| BMS 309403 |脂肪酸結(jié)合蛋白4抑制劑| aP2抑制劑；2-[[[2'-（5-乙基-3,4-二苯基-1H-吡唑-1-基）] [1,1'-聯(lián)苯基] -3-基]氧基]-乙酸

英文名字

A-FABP Inhibitor|ALBP Inhibitor|Adipocyte FABP Inhibitor|BMS 309403|Fatty Acid Binding Protein 4 Inhibitor|aP2 Inhibitor; 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-acetic acid

供應(yīng)商

開(kāi)曼生物

產(chǎn)品貨號(hào)

10010206-10

背景資料

Fatty acid binding protein 4 (FABP4) is a lipid transport protein that is also known as adipocyte FABP and aP2. In addition to adipocytes, it is also abundant in macrophages, along with FABP5, the epidermal FABP.{25740} FABP4 inhibitor is a cell-permeable, potent inhibitor of FABP4 that targets the fatty acid-binding pocket (Ki is = 250 and 350 nM, respectively).{25745} FABP4 inhibitor is orally active, reducing atherosclerosis in mice lacking apoplipoprotein E.{14840,25741} It also protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice.{14840,25744} FABP4 dose-dependently suppresses the release of MCP-1 from macrophages.{25740,25744}

產(chǎn)品描述

A cell-permeable, potent inhibitor of FABP4 (Ki is = 250 a nd 350 nM, respectively); reduces atherosclerosis in mice lacking ApoE and protects against the development of insulin resistance associated with genetic or diet-induced obesity in mice

保存建議

建議您在收到開(kāi)曼生物品牌的FABP4 Inhibitor (10 mg)產(chǎn)品后置于-20度保存，產(chǎn)品有效期為730天.

其他

開(kāi)曼生物向全球科學(xué)工作者提供多研究領(lǐng)域的生化、免疫試劑和分析試劑盒，其產(chǎn)品被廣泛應(yīng)用于腫瘤、氧化氮、神經(jīng)學(xué)、凋亡、氧化性損傷、內(nèi)分泌學(xué)等不同研究領(lǐng)域.開(kāi)曼生物可提供用于檢測(cè)的特色試劑盒，如：類(lèi)花生酸類(lèi)物質(zhì)、游離的生物標(biāo)志、環(huán)核苷、激素及氧化氮等；也提供多種高質(zhì)量試劑，包括：類(lèi)花生酸類(lèi)物質(zhì)、氧化氮試劑及許多相關(guān)脂質(zhì)、脂肪酸、酶和抗體