Herpes simplex infections of the skin and mucous membranes including genital herpes (initial and recurrent) if given as soon as possible after symptoms appear.
Suppression of recurrent herpes simplex infections in patients with a incompetent immune system. Indicated for shingles if the lesion is not older than 72 hours.
If used within 24 hours after appearance of typical chickenpox rash, acyclovir is indicated for treatment of the Varicella Zoster or chickenpox virus.
In HIV positive patients, who are severely immuno-compromised, acyclovir is indicated to reduce the risk of developing herpes infections. Acyclovir could be used in combination with zidovudine in patients with advanced HIV disease.