別名

Resveratrol - CAS 501-36-0 - Calbiochem,trans-3,4ʹ,5-Trihydroxystilbene

一般描述

A phenolic product found in both grape skin and wines. Has anti-fungal, anti-tumor and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 μM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 μM). Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 μM) and acts as an anti-mutagenic agent (ED50 = 15 μM) in TM677 cells treated with DMBA. Also selectively inhibits P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells. A phenolic product found in both grape skins and wines. Has antifungal, antitumor, and antioxidative properties. A specific inhibitor of cyclooxygenase-1 (COX-1; ED50 = 15 μM). Also inhibits the hydroxyperoxidase activity of COX-1 (ED50 = 3.7 μM). Strongly inhibits insoluble transthyretin (TTR) amyloid fibril formation. Inhibits phorbol ester-induced free radical formation in HL-60 cells (ED50 = 27 μM) and acts as an anti-mutagenic agent (ED50 = 15 μM) in TM677 cells treated with DMBA. Also a selective inhibitor of P450 1A1. Reported to activate sirtuins and promote the survival of eukaryotic cells.

生化/生理作用

Cell permeable: no ED50 = 15 μM against COX-1 Primary Target
COX-1 Product does not compete with ATP. Reversible: no

重懸

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說(shuō)明

Howitz, K.T., et al. 2003. Nature425, 191.
Lin, H.Y., et al. 2002. J. Urol.168, 748.
Klabunde, T., et al. 2000. Nat. Struct. Biol.7, 312.
Chun, Y.J., et al. 1999. Biochem. Biophys. Res. Commun.262, 20.
Jang, M., et al. 1997. Science 275, 218.
Chen, C.K., et al. 1996. Gen. Pharmacol.27, 363.