產(chǎn)品屬性：
產(chǎn)品名稱 | 規(guī)格 | CAS號 | 型號 |
Adenosine-5'-diphosphate | 100mg 250mg 500mg 1g | 58-64-0 | EY-Y0163750 |
Cas No.58-64-0
別名 Adenosine Pyrophosphate,ADP,5′-ADP
化學(xué)名 adenosine 5'-(trihydrogen diphosphate)
分子式 C10H15N5O10P2
分子量 427.2
溶解度 ≥ 21.35mg/mL in DMSO with gentle warming
儲存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
IC50: 67 nM for P2X2/3
Adenosine-5'-diphosphate is an agonist of purinergic receptors.
Purinergic receptors, also known as purinoceptors, are a family of plasma membrane molecules that are found in almost all mammalian tissues. Within the field of purinergic signalling, these receptors have been implicated in learning and memory, locomotor and feeding behavior, and sleep. More specifically, purinergic receptors are involved in several cellular functions, such as proliferation and migration of neural stem cells, vascular reactivity, apoptosis and cytokine secretion.
In vitro: Adenosine 5'-diphosphate (ADP) is an adenine nucleotide having two phosphate groups esterified to the sugar moiety at the 5’ position. ADP is formed through dephosphorylation of adenosine 5’-triphosphate (ATP) by ATPases and can be converted back to ATP by ATP synthases. ADP can also be metabolized to adenosine 5’-monophosphate (AMP) and 2’-deoxyadenosine 5’-diphosphate (dADP). ADP can modulate several receptors, such as activating certain purinergic receptors and inhibiting others, inhibiting rat ecto-5’nucleotidase (Ki = 0.91 nM), as well as regulating the phosphorylation status of AMP-activated protein kinase [1, 2].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
關(guān)鍵字： 58-64-0;C10H15N5O10P2;Adenosine-5'-diphosp;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷售企業(yè)，公司自成立以來，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類大中小醫(yī)院及其它醫(yī)療機構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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